School of Medicine: Recent submissions
Now showing items 221-240 of 3444
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The development and applications of a child-centred Well-Being Index : findings from a longitudinal project using data from the Growing Up in Ireland study
(Trinity College (Dublin, Ireland). Department of Public Health and Primary Care, 2017)The children of today are the adults of tomorrow. Therefore, children's well-being is relevant for the current and future society. In this context, the study of well-being of children and young people has received great ... -
Structural and functional characterisation of interleukin 8 haplotypes in cattle
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Accumulation of leukocytes in the tissue is one of the hallmarks of inflammation. In bovine mastitis and uterine disease neutrophils are rapidly recruited to either the mammary gland or the uterus. This leads to an increase ... -
Inflammatory bowel disease in Ireland : epidemiology of an Irish inception cohort - results from a perspective long-term follow-up study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Ulcerative Colitis (UC) and Crohn’s Disease (CD) constitute the two main forms of Inflammatory Bowel Disease (IBD). They are chronic relapsing conditions of the gastrointestinal tract with occasional extra-gastrointestinal ... -
Regional specific modulation of neuronal activation associated with the antidepressant-related properties of neuronal nitric oxide synthase (nNOS) inhibitors
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Depression is a significant health problem in today’s society and when left untreated can be a devastating illness. Current antidepressant treatments are far from ideal as several weeks are required for a therapeutic effect, ... -
Protective effects of noradrenergic and neurotrophic signalling on neuronal complexity in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Neuronal atrophy and synaptic dysfunction are prevalent features of a range of neurological disorders. Degeneration of neurites and loss of synaptic connections often precede cell loss during neurodegeneration and the ... -
Towards fit for purpose final assessment of clinical skills in medical graduates
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2017)Background: The assessment of broader competencies of skills and attributes beyond knowledge are expected graduate outcomes in a medical degree. Assessment must provide explicit evidence of student learning. The quality ... -
Exploring the role of lipoxygenases in oesophageal cancer and the anti-angiogenic potential of novel lipoxgenase inhibitors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Over the past decade there has been a dramatic increase in the incidence of oesophageal cancer in Ireland, which has the third highest incidence rate in Europe. This is mainly due to rising numbers of the oesophageal ... -
Post-genomic investigation of coeliac susceptibility genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Coeliac Disease (C) is a debilitating condition characterised by chronic inflammation of the small intestine. This autoimmune disorder is triggered in genetically predispsed individuals following ingestion of dietary gluten, ... -
Polypharmacy and potentially inappropriate prescribing in community dwelling people living with Alzheimer's dementia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Older adults are the biggest consumers of medications worldwide(1), however they are underrepresented in the clinical literature. This is true also for people living with dementia who are often excluded from clinical ... -
Dysregulated cell signalling as an oncogenic basis for the development of clear cell sarcoma of kidney (CCSK)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Clear cell sarcoma of the kidney (CCSK) is a poorly understood, aggressive, therapy resistance cancer of childhood. The lack of consistent histological or immunohistochemical features of CCSK can make this a diagnostic ... -
Cancer stem cells : the root of cisplatin resistance in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Lung cancer is the leading cause of cancer-related death in Ireland and worldwide. Despite advances in anti-cancer therapies, the overall 5-year survival for non-small cell lung cancer (NSCLC) remains poor (<15%). As such, ... -
The cost-effectiveness of Hepatitis C treatments in Ireland : a multi-technology assessment
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2016)Introduction Chronic Hepatitis C (HCV) is an important public health concern with an estimated 20,000 to 50,000 people infected in Ireland. Horizon scanning at the National Centre for Pharmacoeconomics in 2011 identified ... -
Investigation the role of T cells in the progression of reflux oesophagitis to Barrett's oesophagus and oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Oesophageal adenocarcinoma (OAC) is an inflammatory driven cancer that arises on a background of gastro-oesophageal reflux disease (GORD) and Barrett’s oesophagus (BO). T cells have been implicated in the initiation of ... -
Nursing home residents in the Emergency Department (NuHR-ED): a review of resident characteristics and outcomes following Emergency Department attendance and the impact of a Nursing Home Liaison Service
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Nursing Home (NH) residents are among the most vulnerable members of society. High rates of multimorbidity, functional dependence and frailty lead to high levels of health and social care needs in this cohort. ... -
Analysis of the metabolic shift that accompanies differential activation of microglia
(Trinity College (Dublin, Ireland). Department of Physiology, 2017)Microglia, the resident immune cells of the central nervous system (CNS), adopt different phenotypes upon activation by different stimuli. The primary role of microglia is protection and maintenance of homeostasis, and any ... -
Excercise and TrkB activation as neuroprotectants in mouse models of age and neuroinflammation : an assessment of underlying mechanisms
(Trinity College (Dublin, Ireland). Department of Physiology, 2017)The processes of learning and memory concern themselves primarily with the hippocampus - one of two exclusive cortical regions where neurogenesis has been found to take place. These cognitive processes are themselves ... -
Oesophageal adenocarcinoma cell migration and metastasis : an investigation of the scaffolding protein RACK1 as a key player and therapeutic target
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)The incidence of oesophageal adenocarcinoma is increasing at a rapid rate in Western countries (Pennathur et al., 2013). Early oesophageal cancer is often asymptomatic and metastatic disease is common at presentation leading ... -
The effect of cigarette smoking on inflammatory, immunological and metabolic profiles in ulcerative colitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Ulcerative Colitis (UC) is an idiopathic form of inflammatory bowel disease characterised by chronic or relapsing inflammation in the colon. The pathogenesis of UC remains largely unknown but it is widely believed to be ... -
Importance of energy metabolism, angiogenesis and DNA repair in regulating neoadjuvant radiosensitivity in oesophageal and rectal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Oesophageal and rectal adenocarcinoma are treated with neoadjuvant chemoradiotherapy in order to reduce tumour size prior to surgery, however only 10- 30% of patients have a complete pathological response and there are no ... -
Investigating the role of the transcription factor Rorα in macrophages in the context of development, inflammation and circadian rhythms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Macrophage subsets in tissue sites such as the peritoneal cavity are extremely heterogeneous in their phenotype and functions. These peritoneal macrophage subsets can be of dual origin: monocyte-derived or tissue-resident ...
