School of Medicine: Recent submissions
Now showing items 241-260 of 3444
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An exploration of gait parameters and heart rate recovery in older adults with orthostatic hypotension
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)It is known that there is an ageing population globally, and with ageing comes physiological and function decline. The prevalence of many health conditions increases with advancing age, including orthostatic hypotension. ... -
An Exploration of the feasibility of establishing a benchmark European examination in Clinical Microbiology
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, Trinity College Dublin, School of Medicine, 2024)Recruiting doctors in Clinical Microbiology (CM) in Ireland is challenging, and partly hindered by different training & scope of practice in CM across countries. Doctors training in CM in Ireland are required to sit a UK ... -
A numerical, phenotypical and functional characterization of innate T cell populations in CVID
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Common Variable Immunodeficiency (CVID) is a primary antibody deficiency characterized by widespread B cell defects, low serum immunoglobulin levels, recurrent infections and frequent idiopathic complications, including ... -
Task-shifting in mental health services : extent, impact and challenges in Ghana
(Trinity College (Dublin, Ireland). Centre for Global Health, 2016)Aim: To examine the role and scope of practice of Community Mental Health Workers (CMHWs) as well as the impact and challenges associated with the work of CMHWs within Ghana's mental health delivery system, and to explore ... -
Modifiable Risk Factors for dementia, awareness of, and barriers to, brain health behaviours
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Dementia is common and in many societies, underdiagnosed. The commonest cause of dementia globally is Alzheimer’s disease. Dementia prevalence is increasing globally. It is estimated that the number of people ... -
Quantitative Image Analysis for the Assessment of Parotid Gland Damage and Toxicity Prediction Following Radiotherapy to the Head and Neck
(Trinity College Dublin. School of Medicine. Discipline of Radiation Therapy, 2024)Patients treated with radiotherapy for head and neck cancer experience debilitating xerostomia and sticky saliva, caused by damage to the parotid glands. Currently predicting this toxicity is limited by the inability of ... -
"Playing catch-up" Safety and Optimal tackle outcomes in Women's Rugby Union.
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)The frequency and impact of tackle injuries in Rugby have prompted calls to mitigate the associated risks within the Sport. Although women's Rugby is considered one of the fastest growing sports worldwide, research has not ... -
Investigating the Epidemiology of Mycobacterium bovis Infection in Humans in Ireland.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Mycobacterium bovis is the main cause of bovine tuberculosis. It can cause zoonotic infection in humans. An average of 6 human M. bovis infections are notified annually in Ireland. Little is currently known about the ... -
Patient-derived tau and amyloid-beta facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response
(2024)Alzheimer’s disease is characterized by progressive cognitive decline in older individuals accompanied by the deposition of two pathognomonic proteins amyloid β (Aβ) and tau. It is well documented that synaptotoxic soluble ... -
An exploration of the clinical characteristics and the impact of symptomatic hypermobility in children, adolescents, and their families
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)Background: Children and adolescents with symptomatic hypermobility can present with chronic musculoskeletal pain and dysfunction, along with a wide variety of multi-systemic complaints. Clinical heterogeneity poses a ... -
Anal Cancer Prevention in HIV-Positive and HIV-Negative Men who have Sex with Men: (Exploring Screening tests of Another Disease State (Cervical Cancer) to Inform Future Screening Strategies for Anal Cancer and its Precursor Lesions among a High-Risk Population in Ireland.)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Human Papillomavirus (HPV) is the commonest sexually transmitted infection (STI) in the world. “high-risk” (hr) HPV types are associated with causing or contributing to intraepithelial neoplasia and carcinoma ... -
Small-Bowel Capsule Endoscopy Optimising Capsule Endoscopy in Clinical Practice
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)This thesis evaluated three aspects of the clinical application of small bowel cap- sule endoscopy (SBCE). The first section looked at the use of the patency capsule in clinical practice and evaluated its limitations. ... -
A PROSPECTIVE ASSESSMENT OF COLON CAPSULE ENDOSCOPY AS A COLONIC POLYP SURVEILLANCE TECHNIQUE IN IRELAND, AND FUTURE DEVELOPMENTS
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Colorectal cancer (CRC) has a significant global impact in terms morbidity and mortality. Our knowledge of its natural course, and its growth from a precursor lesion as a polyp, gives us the opportunity to prevent CRC ... -
Elucidating the therapeutic potential of Q8 in Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in humans. Despite advancements in treatment and care, patient outcomes and survival rates are abysmal, with a five-year survival rate ... -
Economic evaluation of public health interventions
(Trinity College (Dublin, Ireland). School of Medicine. Centre of Health Policy and Management, 2016)This thesis examines the clinical and cost effectiveness of three separate public health interventions that are on the health policy agenda in Ireland and provides information to inform resource allocation at a national ... -
Cortical Network Activity Predicts IGF-1 Treatment Response in Rett Syndrome
(2019)Background: Rett Syndrome is a neurodevelopment disorder associated with mutations in the gene MECP2, which is involved in the development and function of cortical networks. This dysfunction results in specific ... -
Analysis of the Outcomes of Micro-Vascular Reconstruction following the Management Head and Neck Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024) -
Investigating Molluscum Contagiosum Virus Protein MC009 as a Novel Inhibitor of Human Innate Immune Signalling
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes mild, raised skin lesions which are highly contagious. The lesions are notable for exerting minimal to no inflammation but can persist for long ... -
Exploring the Experiences of Autistic Graduate Women in Navigating the World of Work
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)International research highlights poor prospects for autistic individuals in gaining and maintaining work (Baldwin et al., 2014; Harvery et al., 2021; Hendricks, 2010; Maslahati et al., 2022; Scott et al., 2019). Participation ... -
INCOT: Irish Neonatal Care in Occupational Therapy Study: The Development of an Occupational Therapy Intervention for Neonatal Units in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Background: Occupational therapists (OTs) play an important role in neonatal units internationally. This is a growing area of practice in Ireland, but it is not yet part of the standard of care in all neonatal units. ...
