School of Medicine: Recent submissions
Now showing items 341-360 of 3444
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Rett syndrome in Ireland: a demographic study.
(2024)Background: Rett syndrome (RTT) is a rare neurodevelopmental condition associated with mutations in the gene coding for the methyl-CpG-binding protein 2 (MECP2). It is primarily observed in girls and affects individuals ... -
Mental Capacity for Treatment Decisions in Psychiatry Inpatients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)This research aimed to assess the prevalence of mental capacity for treatment decisions in psychiatry inpatients in Ireland and elucidate the relationship, if any, between mental capacity and key clinical and demographic ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
Characterisation of a mutant mouse model of spontaneous atopic dermatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Atopy is Immunoglobulin-E sensitisation to “allergens” such as pollen and food. Atopic dermatitis is a pruritic eczematous dermatitis associated with an early onset in infants. Atopic dermatitis has a complex pathology and ... -
Characterising the progression of haemophilic arthropathy in knee joints of a novel mouse model of severe haemophilia A
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024) -
Neuroimaging correlates of disability in Motor Neuron Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Motor neuron diseases (MND) clinically present with a wide variety of motor and extra-motor symptoms. However, the pathological correlates of such symptom manifestation and their progression is poorly understood. In the ... -
Measuring Successes of Social Prescribing
(2023)Social prescribing is a referral mechanism which connects people to non-medical, community and social based activities, which aim to empower an individual to take control of and manage their health and wellbeing (Husk et ... -
The role of canonical and non-canonical inflammasomes in a model of oxidative stress-induced retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases like age-related macular degeneration (AMD) are a leading cause of visual impairment. Oxidative stress is known to be important in the pathogenesis of AMD, and oxidative-stress induced retinal ... -
Supportive care: the "keystone" of modern oncology practice
(2023)The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and ... -
Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Purpose: The purpose of this scoping review is to appraise the published literature on taste disturbance in patients with advanced cancer, with the specific objectives being to determine its prevalence, clinical features ... -
Circadian rhythm disorders in patients with advanced cancer: a scoping review
(2023)Circadian rhythms can be demonstrated in several biomarkers and behavioural activities, with rhythmical patterns occurring roughly over a 24-h period. Circadian disorders occur in patients with cancer and may be associated ... -
Challenges to delivering evidence-based palliative medicine
(2023)Established as a medical specialty in 1987, palliative medicine approaches middle age facing existential questions of identity, purpose and vision. Time has weakened strong foundations laid by Dame Cicely Saunders in ... -
Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Background: The aim of this project was to review the literature on dry mouth / xerostomia in patients with advanced cancer, with the objectives being to determine its prevalence, clinical features, and complications. Methods: ... -
Vital signs in palliative care: a scoping review
(2023)Vital signs are routinely measured in secondary healthcare settings and can be used to detect clinical problems, guide treatment, and monitor response to treatment. Vital signs are less frequently measured in palliative ... -
Validation of a French version of the Breakthrough Pain Assessment Tool in cancer patients: factorial structure, reliability and responsiveness
(2023)Objective: Breakthrough cancer pain should be properly assessed for better-personalized treatment plan. The Breakthrough Pain Assessment Tool is a 14-item tool validated in English developed for this purpose; no French ... -
International e-Delphi consensus recommendations for the assessment and diagnosis of circadian rest-activity rhythm disorders (CARDs) in patients with cancer
(2023)Purpose: Circadian rest-Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. ... -
Monthly engagement with EIP keyworkers was associated with a five-fold increase in the odds of engagement with psychosocial interventions
(2024)Background: Early intervention in psychosis (EIP) supports people who are experiencing their first episode of psychosis (FEP). A new Model of Care (MoC) for EIP services was launched in Ireland in 2019. Three EIP demonstration ... -
Barriers and facilitators to the implementation of an early intervention in psychosis service in three demonstration sites in Ireland
(2023)Background: Programmes for early intervention (EIP) in psychosis for people experiencing a first episode of psychosis (FEP) have been found to be both clinically and cost effective. Following the publication of a new EIP ... -
Specialist palliative for patients with cancer: more than end-of-life care
(2023)Palliative care has traditionally focused on end-of-life care for patients with advanced cancer. This has since expanded to include symptom management and quality-of-life improvement from the moment of cancer diagnosis. ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion / guidance on the use of clinically-assisted hydration in patients with advanced cancer
(2024)Purpose: The provision of clinically assisted hydration (CAH) in patients with advanced cancer is controversial, and there is a paucity of specific guidance and so a diversity in clinical practice. Consequently, the ...
