School of Medicine: Recent submissions
Now showing items 361-380 of 3444
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`You can change your life through sports' physical activity interventions to improve the health and well-being of adults experiencing homelessness: a mixed-methods systematic review
(2024)Objectives: Systematically synthesise evidence of physical activity interventions for people experiencing homelessness (PEH). Design: Mixed-methods systematic review. Data sources: EMBASE, Web of Science, CINAHL, ... -
A Cross-Disease Study Investigating the Phenotypic and Functional Heterogeneity in Neutrophil Subsets
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Neutrophils play a critical role in the innate immune response. They are the most abundant leukocytes in humans and are the first line of defence against invading microorganisms; growing evidence in the last decade has ... -
Exploring Neurocognitive Factors Underlying Autism and Hyperphagia in Prader-Willi Syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Background: Prader-Willi Syndrome (PWS) is a rare complex multisystem genetic disorder recognised as the most common genetic cause of life-threatening obesity in humans (Butler, 1996). The PWS genotype gives rise to a ... -
Characteristics and Outcomes of Older Adults Following Distal Forearm Fracture
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Osteoporosis and fragility fractures pose a serious public health challenge in our ageing society. Systems are being developed in Ireland and internationally to provide, coordinated and comprehensive assessments ... -
Resting-state electroencephalographic biomarkers for tracking cognitive network dysfunction in amyotrophiclateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) stands as a multifaceted neurological disorder that primarily affects both upper and lower motor neurons. However, research in neuroimaging, neuropsychology and neurobiology has shown ... -
Barriers to accessing aeroallergen immunotherapy in paediatrics
(2023)Background: Allergen immunotherapy (AIT) is a safe, effective and disease-modifying treatment for allergic rhinitis. It is indicated for children with moderate to severe disease whose symptoms persist despite conventional ... -
Lymph node status and coagulation biomarkers as predictors of venous thromboembolism in gynaecological cancer patients post surgery
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Venous thromboembolism (VTE) is a major complication of cancer ranging from 4- 20% depending on tumour type and stage. VTE risk increases post-surgical treatment especially in the first 90 days post-surgery. The precise ... -
Haploidentical CD3+ TCR αβ/CD19+-depleted HSCT for MHC class II deficiency and persistent SARS-CoV-2 pneumonitis
(2023)Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to coronavirus disease 2019 (COVID-19), which can range from a mild illness to a severe phenotype characterized by acute respiratory ... -
Refining the psychometric properties of the Trinity Student Profile - A self-report measure of occupational performance difficulties within the student role in higher education.
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Background: The Trinity Student Profile (TSP) is a self-report measure of occupational performance difficulties within the university student role and is based on the Person-Environment-Occupation Model. The tool was ... -
Core requirements of frailty screening in the emergency department:an international Delphi consensus study
(2023)Introduction: Frailty is associated with adverse outcomes among patients attending emergency departments (EDs). While multiple frailty screens are available, little is known about which variables are important to incorporate ... -
Long-term outcomes following electroconvulsive therapy for treatment-resistant depression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)Background: Electroconvulsive therapy (ECT) is the most acutely effective treatment for depression but its use is limited by high rates of early relapse and retrograde amnesia of uncertain severity and duration. Aims: ... -
A therapeutic roadmap for ovarian cancer using TLR4 MyD88 and MAD2 as prognostic indicators
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2016)Ovarian cancer is 4th leading cause of cancer death in woman and the most lethal gynaecological malignancy. Most patients present with advanced disease where the 5 year survival rate is less than 40%. Standard treatment ... -
The Role of Exercise Prehabilitation Prior to Oncological Resection
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)Cancer is characterised by uncontrolled cell growth within the body. Surgical resection is the primary curative treatment for solid tumours. However, surgery is invasive and associated with significant morbidity and ... -
Limbic System Development in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Longitudinal Multimodal MRI Analysis
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)While Attention-Deficit Hyperactivity Disorder (ADHD) is characterized by age-related changes in symptoms and brain structures during childhood and adolescence, the link between brain structure and function is less clear. ... -
Clinical characteristics of two groups commonly referred to an Irish hypertension service—patients with resistant hypertension and young adults with hypertension
(2022)Background: The management of hypertension is primarily performed in primary care settings in many health systems. However, two groups of patients often require specialist input: patients with resistant hypertension (RH) ... -
Referrals to, and characteristics of patients attending a specialist hypertension clinic
(2022)The management of hypertension is suboptimal in Ireland and internationally. The role of a specialist hypertension clinic is not always defined but an analysis of the reasons for referral are likely informative. Also, a ... -
Is it time to reconsider the treatment paradigm for obese patients with hypertension?
(2022)The recent STEP trials reported blood pressure reductions for obese patients treated with semaglutide. We analyzed a cohort of patients attending our hypertension clinic and found that 26% were severely or morbidly obese ... -
Neuroimaging features of Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Novelty: Because the vast majority of ALS imaging studies focus on evaluating motor pathology, the focus and novelty of this work is the nuanced characterisation of extra-motor involvement in a genetically stratified cohort ... -
Push and stay factors affecting Irish medical student migration intentions
(2017)Background: A significant proportion of medical students in Ireland have demonstrated strong intentions to migrate following their graduation. Factors influencing these intentions are poorly understood. Our study aimed to ...
