School of Medicine: Recent submissions
Now showing items 421-440 of 3444
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How to harness and improve on video analysis for youth rugby player safety: a narrative review
(2023)Video analysis is a useful tool for injury surveillance in rugby union. There are few video analysis studies in the professional female game, with most studies published in the male elite/professional settings. Moreover, ... -
The Dietary Intake of Patients with Chronic Pancreatitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Chronic pancreatitis is a chronic inflammatory disorder that results in destruction of the endocrine and exocrine function of the pancreas. Due to loss of function, most patient suffer from malabsorption and malnutrition. ... -
Functional clustering of continuous cardiovascular and brain oxygenation signals during an active stand test in The Irish Longitudinal Study on Ageing (TILDA)
(2023)In this study, we performed K-shape functional clustering of two non-invasive continuous cardiovascular (systolic Blood Pressure: sBP) and brain oxygenation (left frontal lobe Tissue Saturation Index: TSI) times series ... -
Circulating tumour cells: The Good, the Bad and the Ugly.
(2023)This review is an overview of the current knowledge regarding circulating tumour cells (CTCs), which are potentially the most lethal type of cancer cell, and may be a key component of the metastatic cascade. The clinical ... -
Estimation of coherence using the median is robust against EEG artefacts
(2017)Coherence is a mathematical measure of correlation in the frequency domain, commonly used to quantify the oscillatory synchrony of bio-signals such as the electroencephalogram (EEG). In biomedical applications, such as ... -
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
(2023)Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ... -
THE DISTINCT AND AGGRESSIVE PATHOGENESIS OF ARTHRITIS IN CHILDREN WITH DOWN SYNDROME
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Juvenile idiopathic arthritis (JIA) is the most common form of inflammatory arthritis (IA) in children. However, recently we described a more aggressive form of IA in children with Down syndrome (DS), termed Down syndrome ... -
Immune Dysfunction and Inflammageing in NAFLD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With a global prevalence of 25-40%, non-alcoholic fatty liver disease (NAFLD) is fast becoming the commonest cause of liver disease in the developed world [1]. Defined as increased hepatic lipid accumulation, approximately ... -
Nursing home staff mental health during the COVID-19 pandemic in the Republic of Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis comprises three main studies. The aim of this project was to characterise nursing home staff mental health during the COVID-19 pandemic in the Republic of Ireland. Study 1: Cross-sectional survey of nursing ... -
A Longitudinal Study of the Complex Needs of Motor Neuron Disease Caregivers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Motor Neuron Disease (MND) is the term used to describe a number of terminal incurable neurodegenerative disorders, of which Amyotrophic Lateral Sclerosis (ALS) is the most common type. MND is characterised by the progressive ... -
FASDcare: Understanding the experiences and needs of family caregivers of people with Fetal Alcohol Spectrum Disorder (FASD) in Ireland
(2023)This report shines a light on the lives of families in Ireland raising a child/children with Fetal Alcohol Spectrum Disorders. Its’ subject matter relates to what is most likely one of the most stigmatized of all health ... -
Evaluation of the Timed Up and Go test for screening vulnerability and frailty in older cancer patients
(2023)Introduction. The need for comprehensive geriatric assessment (CGA) in older adults with cancer is increasing, which makes it necessary to have a screening instrument to identify those who would benefit from this ... -
Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline
(2023)Background: Physical activity and exercise have been suggested as effective interventions for the prevention and management of mild cognitive impairment (MCI) and dementia, but there are no international guidelines. Objectives: ... -
Leveraging a national patient registry to explore relapse in ANCA associated vasculitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)BACKGROUND ANCA associated vasculitis (AAV) is an archetypal rare autoimmune disease, resulting in immune-mediated organ damage. It has a relapsing-remitting course, resulting in cumulative morbidity and mortality. Toxic ... -
An evaluation ofthe Allostatic Load framework for quantifying differences inhealth and longevity
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2023)The Allostatic Load (AL) framework posits that chronic or repeated exposure to stressors can cause dysregulation of multiple interrelated physiological systems, which if prolonged, may ultimately lead to deteriorations in ... -
Evaluation of a 3-Item Health Index in Predicting Mortality Risk: A 12-Year Follow-Up Study
(2023)This study was carried out using a large cohort (N = 4265; 416 deceased) of older, community-dwelling adults from The Irish Longitudinal Study on Ageing (TILDA). The study compared the performance of a new 3-item health ... -
The Use of the World Guidelines for Falls Prevention and Management's Risk Stratification Algorithm in Predicting Falls in The Irish Longitudinal Study on Ageing (TILDA)
(2023)Background: the aim of this study was to retrospectively operationalise the World Guidelines for Falls Prevention and Management (WGFPM) falls risk stratification algorithm using data from The Irish Longitudinal Study on ... -
The Neuroimaging Features of Frontotemporal Dementia: Characterising Phenotype-Associated Pathological Changes In Vivo
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frontotemporal dementia (FTD) is a rare type of dementia. It can affect language, behaviour and memory depending on what part of the brain is involved. It can be difficult to diagnose, especially in the early stages of ... -
The Contribution of Additional Genetic Variation to CNV Carrier Cognitive and Neurodevelopmental Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Many copy number variants (CNV) are strongly associated with neurodevelopmental disorders (NDDs) such as autism, intellectual disability/developmental delay (ID/DD) and schizophrenia. CNVs are large genomic deletions or ... -
Real-world outcomes with recombinant factor IX Fc fusion protein in people with haemophilia B in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemophilia B is a rare X-linked bleeding disorder resulting from a deficiency of clotting factor IX (FIX), with severe haemophilia B defined as FIX levels < 0.01 IU/mL. Severe haemophilia is characterised by haemarthrosis, ...
