School of Medicine: Recent submissions
Now showing items 441-460 of 3444
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CRADLE - Circadian Rhythm Alteration anD neonataL Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2023)Background: Neonatal Encephalopathy (NE) is a clinically defined syndrome of disturbed neurological function in the earliest days of life in term and near-term newborns. NE remains a major cause of mortality and morbidity ... -
Feasibility of OptiMaL, a Self-Management Programme for Oesophageal Cancer Survivors
(2023)Introduction: There is limited availability of self-management interventions for oesophageal cancer survivors at present. This study examined the feasibility of OptiMal, a six-week, self-management programme to improve ... -
Strategy Selection and Comparison in the Cost-Effectiveness Analysis of Cancer Screening
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2023)Cost-effectiveness analysis (CEA) is well-established in application to cancer screening programmes. CEAs of screening differ from analyses of therapeutic interventions as the choice of strategies for comparison is not ... -
Coercion and Involuntary Care: A Study of Involuntary and Voluntary Psychiatry Inpatients in Dublin
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Involuntary care is a feature of mental health services around the world. In addition to involuntary admission and treatment, specific coercive or restrictive practices including seclusion and physical restraint occur in ... -
A Longitudinal Study of the Evolution of Neuropsychological Change in Amyotrophic Lateral Sclerosis: The Incidence, Nature and Progression of Language Impairment.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Amyotrophic Lateral Sclerosis is a multi-system disease that also affects cognition and behaviour. Cognitive change in ALS manifests most commonly as executive dysfunction. Although changes in language function ... -
Exploring the influence of obesity, fatty acids, and current treatment modalities on the immune-metabolic profiles of adipose tissue in oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with ... -
Integrative multi-omic analytics for the early detection of pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic cancer (PC) has the lowest 5-year survival rate of any cancer, at just 12% in 2023. The poor survival rates observed in this cancer are the result of an accumulation of shortcomings and gaps in many aspects of ... -
Interrupting Bedtime to Reverse Frailty Levels in Acute Care: A Study Protocol for the Breaking Bad Rest Randomized Controlled Trial
(2023)Background Hospitalized older patients spend most of the waking hours in bed, even if they can walk independently. Excessive bedrest contributes to the development of frailty and worse hospital outcomes. We describe the ... -
Comprehensive geriatric assessment and clinical outcomes of frail older adults with diffuse large B-cell lymphoma: a metanalysis
(2023)Introduction. Comprehensive geriatric assessment (CGA) is used to personalize cancer treatments in frail older adults. However, its utility to guide treatments in frail older patients with diffuse large B-cell lymphoma ... -
COVID-19 in Irish Hospital Healthcare Workers; SARS-CoV-2 antibody prevalence, epidemiology of infection and antibody response to vaccination
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background Hospital healthcare workers (HCW) are at increased risk of contracting COVID-19 infection. We aimed to determine the seroprevalence of SARS-CoV-2 antibodies in HCW in Ireland in two locations with diverging ... -
Physical functioning and health-outcomes following hospitalisation with COVID-19: a longitudinal cohort study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction: A novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) emerged in Wuhan, China in late 2019, causing an outbreak of viral pneumonia. Initial studies published focused on the management ... -
Novel Mechanisms of Resistance to Enzalutamide in Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Prostate cancer (PCa) is the second most common invasive cancer in men worldwide. In Ireland, PCa is the third leading cause of male cancer related mortality. AR directed therapies have remained the primary therapeutic ... -
Facilitating readiness for advance care planning in Ireland: Informing the design of an innovative intervention for middle aged and older people in the community
Background: Advance care planning (ACP) is a process aiming to elicit, communicate, and document future care wishes, providing mechanisms through which individual preferences can be supported. Poor and fragmented ... -
Targeting the prostate cancer metabolome with novel trojan horse compounds.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023)Prostate cancer (PCa) is the second most common cancer diagnosed in males worldwide, and the incidence of this disease is predicted to double globally by 2030. In Ireland, PCa accounts for nearly 16% of all invasive cancers ... -
Investigation of the role of the complement system in the radioresistance of rectal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Colorectal cancer (CRC) is the third most common cancer globally, accounting for approximately 10% of all cancer diagnoses. A third of CRCs occur in the rectum. The majority of CRCs are diagnosed at advanced stages and ... -
Identification of predictors of gait speeds in The Irish Longitudinal Study on Ageing using automated feature selection and explainable machine learning
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2023)This work reports the novel application of automated feature selection and explainable machine learning to identify and compare, in participants aged 50 years or over from wave 3 of The Irish Longitudinal Study on Ageing ... -
The Age-Old Question of ANCA-Associated Vasculitis
(Trinity College Dublin. School of Medicine. Medical Gerontology, 2023)Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis (AAV) is a group of systemic autoimmune disorders characterised by severe inflammation of the small blood vessels. Unusually for an autoimmune disease, ... -
An Analysis of the Biopsychosocial Factors including Sex and Pregnancy in Women with Axial Spondyloarthritis; Data from the Ankylosing Spondylitis Registry of Ireland (ASRI)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With advances in pathophysiology, development of novel classification criteria and the advent of new therapeutic agents the field of axial spondyloarthritis (axSpA) is rapidly evolving. Despite this, the impact and interplay ... -
Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA) Student: Patrick O?Donoghue ... -
“Dancing with Atoms”: A tribute to Sheila Tinney
(2023)The authors present a short dynamic visualization titled “Dancing with Atoms”, produced in honor of the late Irish mathematical physicist Sheila Tinney (1918--2010), the first Irish-born and -raised woman to receive a ...
