School of Medicine: Recent submissions
Now showing items 461-480 of 3444
-
Older Hospitalised Patients' Reported Confidence in Managing Discharge Needs: a Retrospective Observational Study
(2023)Objectives: To evaluate the introduction of a patient-reported outcome measure (PROM) of self-confidence in managing discharge needs in an acutely hospitalised older adult population. Methods: A retrospective service evaluation ... -
Harnessing natural killer cell-mediated immune responses in obesity-associated cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophagogastric adenocarcinomas (OAC) encompass a group of inflammation-driven and obesity-associated cancers. Poor 5-year survival rates of less than 20% and treatment response rates of less than 30% place these as poor ... -
The Impact of Socio-Demographic and Clinical Factors on Acute Medical Service Utilisation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Socio-economic status impacts health throughout the lifecycle. It does this by affecting income, accommodation, access to education and skills, and access to healthcare. This mediates the phenotypic expression of disease ... -
Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ... -
The innate immunomodulatory effects of Aquamin in the context of the metabolic syndrome
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2023)Metabolic disease is a combination of conditions that manifest together, elevating the risk for cardiovascular disease, type 2 diabetes and stroke. Inflammation is a major contributor in the pathophysiology of metabolic ... -
Optimising the In-Hospital Management of Hip Fracture Using the Irish Hip Fracture Database
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hip fracture can have a devastating impact on older adults as it is associated with reduced life expectancy, loss of independence and poorer quality of life. Each year in Ireland approximately 3,600 patients experience a ... -
Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
Residential Long-Term Care and the Built Environment: Balancing Quality of Life and Infection Control
(2023)Objectives: This article explores expert insights into residential long-term care (RLTC), specifically regarding the built environment, its impact on infection control (IC) measures and on resident, staff, and family ... -
Turkish version of the SHARE-Frailty Instrument for primary care: reliability and validity in the nursing home setting
(2023)In Turkey, physical frailty instruments have not been studied in the nursing home setting. We determined the reliability and validity of a Turkish version of the SHARE-Frailty Instrument for primary care (SHARE-FI) in ... -
Vitamin D in the Irish Population: an analysis of prevalence and determinants
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2023)Introduction: Vitamin D has an established role in bone and muscle health, with deficiency causing rickets in children, osteomalacia in adults and contributing to the development of osteoporosis. More recently it has been ... -
Physical function in community-dwelling older adults - a focus on health inequality and ageing in place
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis sought to explore socioeconomic determinants of physical function in community-dwelling older adults, with implications for ageing in place. While several markers of physical function are explored in this thesis, ... -
Neuroimaging to Assess Neonatal Brain Development and Brain Injury in Neonatal Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Neonatal encephalopathy (NE) is a clinical syndrome describing perinatal brain injury and neurological dysfunction in the term-born infant. Magnetic resonance imaging (MRI) is a widely used tool in the assessment of NE, ... -
Work like a Doc: A comparison of regulations on residents' working hours in 14 high-income countries
(2023)Background: Medical residents work long, continuous hours. Working in conditions of extreme fatigue has adverse effects on the quality and safety of care, and on residents' quality of life. Many countries have attempted ... -
The PRESTO report. Sustainability and Resilience in the Irish Health System
(Trinity College Dublin/London School of Economics/Partnership for Health System Sustainability & re, 2023)The recovery of the Irish health system from the COVID-19 pandemic provides an opportunity for reflection and learning. COVID-19 has tested health systems in the extreme and spotlighted long- standing weaknesses. This ... -
Radioiodine Dosimetry for Benign and Malignant Thyroid Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Thyroid diseases are a common clinical disorder with 5-10% diagnosed as thyroid cancer. The published guidelines that provide clinical guidance for the diagnosis, treatment and management of thyroid diseases, based on a ... -
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
(2023)Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into ... -
Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid
(2023)Objective: Orthostatic intolerance (OI) is common in Long Covid. Physical counterpressure manoeuvres (PCM) may improve OI in other disorders. We characterised the blood pressure-rising effect of PCM using surface ... -
The frail brain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background and aims: Frailty in older adults has been associated with reduced brain health and greater risk of cognitive decline. However, structural and functional brain signatures of frailty remain understudied, with ... -
"Body on the line": experiences of tackle injury in women s rugby union a grounded theory study
(2023)Objectives Tackle-related injuries account for up to 67% of all match injuries in women’s rugby union. The perspective of women players on tackle injury can help key stakeholders understand psychosocial determinants of ... -
Clinical Decision Support for the Assessment of Syncope and Falls: Novel Applications of Cerebral Perfusion Measurement and Big Data Analytics
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2023)Syncope, defined as a transient loss of consciousness due to cerebral hypoperfusion, is common in both young and old, with syncope an attributable cause of unexplained falls (UF) in older adults. Both syncope and falls ...
