School of Medicine: Recent submissions
Now showing items 601-620 of 3444
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An exploration of the role of the clinical academic and strategies to sustain and build the clinical academic workforce
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Clinical academics are critical to delivering high quality patient care and discovering new ways to treat disease (1), however the clinical academic workforce is shrinking (2-4). There is a need to clearly ... -
Perinatal Depression and Children's Developmental Outcomes at 2 and 3 Years Postpartum
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Depression is the most common perinatal psychiatric disorder and has been associated with a range of adverse outcomes for children, parents and overall family functioning. The current thesis sought to build on existing ... -
Advanced histology methods for biodistribution and safety screening of next generation nanobiomaterials
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Over the past few decades nanobiomaterials (NBMs) have shown a promise in improving many areas of medicine such as diagnosis and treatment of diseases, with number of formulations currently approved for use by the regulators. ... -
An evaluation of pre-qualification respiratory physiotherapy curricula on the island of Ireland
(2022)BACKGROUND: Respiratory physiotherapy is a core area of practice, but little is known about pre-qualification physiotherapy curricula across institutions. The purpose of this study was to identify and categorise the ... -
Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: An International Delphi Consensus Statement of the International CApsule Endoscopy REsearch (I-CARE) Group.
(2022)Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique ... -
What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis
(2017)Introduction: ALSFRS-R is the most widely used functional rating system in ALS patients. However, heterogeneity in ALSFRS-R progression renders analysis challenging. We have explored the characteristics of total ALSFRS-R, ... -
Food Allergy among Irish Children: An Exploration of the Risk and Impact of Accidental Allergic Reactions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction Food allergy (FA) now impacts almost 1 in 20 Irish children. These children are at risk of allergic reactions and anaphylaxis. Food is an integral part of all social activities, and thus children with FA ... -
The role of intermediaries in connecting community-dwelling adults to local physical activity and exercise: A scoping review protocol [version 2; peer review: 2 approved]
(2022)Introduction: Physical inactivity is a major global issue affecting health. Promoting, supporting and encouraging physical activity amongst community-dwelling adults is essential. An intermediary is a clinical or non-clinical ... -
Combination radiotherapy and immunotherapy: effects on the immune landscape of oesophageal adenocarcinoma and the multimodal therapeutic paradigm
The incidence of cancer of the oesophagus and the gastro-oesophageal junction (GEJ) has increased exponentially in the western world over the last half century. Oesophageal adenocarcinoma (OAC) is now the dominant subtype, ... -
Evaluation of Next-Generation Sequencing to Investigate the Epidemiology of Clostridioides difficile Infection
Introduction: Clostridioides difficile (C. difficile) is an anaerobic bacteria, which can cause gastrointestinal infection. There are approximately 2,000 cases of C. difficile infection (CDI) diagnosed in Ireland per year, ... -
The development and feasibility of the occupational therapy-led `Work and Cancer' intervention for women living with and beyond breast cancer
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2022)Background: Increased survivorship has prompted focus on optimising quality of life for those living with and beyond cancer, including reintegration into work. Despite frequently cited return-to-work barriers for women ... -
How Local Decision Making Works for Adaptations of Health Interventions During Scale-up: A Realist Review
Introduction: Scaling-up health interventions is a complex process with growing recognition of the need to make adaptations to interventions to address diverse contexts and populations encountered across multiple sites. ... -
Association between low serum vitamin d and Increased mortality and severity due to COVID-19: reverse causality?
(2022)We are very close to completing two years since the start of the COVID-19 pandemic. Even though vaccines have been developed and applied to more than 4 billion people in the world, SARS-CoV-2 continues to be a challenge ... -
Comprehensive clinical characterisation of brain fog in adults reporting long COVID symptoms
(2022)(1) Introduction: A subset of individuals experiencing long COVID symptoms are affected by ‘brain fog’, a lay term that often refers to general cognitive dysfunction but one that is still poorly characterised. In this ... -
End-Of-Life Decision Making A Novel Entrustable Professional Activity?
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Introduction: Making tough decisions about End-Of-Life situations and palliative care in acute surgical scenarios is a non-technical skill surgeons have to master over a number of years of experience. Data suggests that ... -
Thrombin generation parameters, relationship with cerebral micro-embolic signal status, and a systematic review of the literature on platelet biomarkers in patients with symptomatic and asymptomatic carotid stenosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background:?Activation of platelets and the coagulation system are integrally involved in acute thrombus formation and distal thrombo-embolism. A better understanding of these complex thrombotic and haemostatic pathways ... -
The effectiveness of smoking cessation interventions for socio-economically disadvantaged women: a systematic review and meta-analysis
(2022)Introduction: This systematic review and meta-analysis assessed the effectiveness of smoking cessation interventions among women smokers in low socio-economic status (SES) groups or women living in disadvantaged areas who ... -
Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ...
