School of Medicine: Recent submissions
Now showing items 781-800 of 3444
-
Three-dimensional (3D) hepatic cell culture models to improve the clinical translation of nanobiomaterials (NBMs)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Despite the wide-reaching applications of nanoparticles that may be used for medical applications, i.e. nanobiomaterials or NBMs, in human health and medicine, their translation to the clinic is staggering slow, with a ... -
Comparison of balance variables across active and retired athletes and age matched controls
(2021)Postural control is a major falls risk factor, therefore identifying protective mechanisms is essential. Physical activity enhances postural stability but effect duration has been minimally researched. The current study ... -
Epidural Spinal Cord Stimulation for motor recovery in SCI: A Systematic Review
(2021)Background. Epidural spinal electrical stimulation at the lumbar spinal level evokes rhythmic muscle activation of lower-limb antagonists, attributed to the central pattern generator. However, the efficacy of noninvasive ... -
Functional deficits in post-operative adolescent idiopathic scoliosis patients
(2020)BACKGROUND: Little or no research currently exists investigating musculoskeletal strength, joint flexibility and cardiopulmonary capacity post-operative adolescent idiopathic scoliosis (AIS) patients. PURPOSE: To explore ... -
ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients
(2019)Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the third leading cause of death worldwide. Recent reports have indicated that dysfunctional iron handling in the lungs of COPD ... -
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
(2019)The prevalence of obesity is rising worldwide, and obese patients constitute a specific population in the intensive care unit. Acute respiratory distress syndrome (ARDS) incidence is increased in obese patients. Exposure ... -
Mitochondrial Iron in Human Health and Disease
(2019)Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria encompass an active organellar network that fuses, divides, and directs a myriad of vital biological functions, including energy metabolism, ... -
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
(2019)Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type 2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis. However, the role of mitochondrial ... -
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort
(2020)BACKGROUND: Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly ... -
Platelet-cancer Cell Interactions induce PAI-1 Expression in an Ovarian Cancer Cell Line Model: Implications for the Metastasis of Epithelial Ovarian Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2021)This thesis encompasses an investigation into the function of plasminogen activator inhibitor 1 (PAI-1) - a serine protease inhibitor integral to coagulation and fibrinolysis that has been identified as both a key factor ... -
Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
(2021)Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate ... -
Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease
(2020)Metabolic plasticity involving shifts between mitochondrial respiration and glycolysis is emerging as a crucial component of innate immune cell function. The number of alveolar macrophages (AMs), the most abundant ... -
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
(2020)Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but theimportance and regulation of these changes remain unclear. We found that hepcidin, themaster regulator of systemic iron homeostasis, ... -
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
(2020)Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage fluid of individuals with chronic obstructive pulmonary disease (COPD), when compared to healthy controls. Whether more ... -
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort
(2021)Background: There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release ... -
Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2
(2021)Determining the layers of gene regulation within the innate immune response is critical to our understanding of the cellular responses to infection and dysregulation in disease. We identified a conserved mechanism of gene ... -
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study
(2021)Introduction:Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), butthe effect of frailty has been unclear.Methods:This multi-centre cohort study involved patients aged 18 ... -
Making healthcare accessible for single adults with complex needs experiencing long-term homelessness: A realist evaluation protocol
(2021)Background: Over the last several years, homelessness has increased in Ireland and across Europe. Rates have recently declined since the coronavirus disease 2019 (COVID-19) pandemic, but it is unclear whether emergency ... -
Improving access to epilepsy care for homeless patients in the Dublin Inner City: a collaborative quality improvement project joining hospital and community care
(2021)Homelessness is associated with significant psychosocial and health disparities. The rate of epilepsy among this cohort is eight times greater than that in the settled population, and the associated morbidity is higher due ...
