School of Medicine: Recent submissions
Now showing items 801-820 of 3444
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Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial cell activation
(2021)Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonarymicrovascular occlusion, which is a hallmark of severe coronavirus disease 2019(COVID-19). Consistent with EC activation, increased plasma ... -
Evaluation of an eLearning teaching innovation to assist clinical radiation therapy educators in the provision of student feedback
(2021)Background: Clinical placement is an integral part of the Radiation Therapy undergraduate programme. Feedback and formative assessment during clinical placement are regarded as key to developing clinical skills and ... -
Perceptions of fatigue and fatigue management interventions among people with multiple sclerosis: A systematic literature review and narrative synthesis
(2021)Background/Aims: Fatigue is the most common symptom of multiple sclerosis. Evidence supports the effectiveness of fatigue management interventions for people with multiple sclerosis. This review aimed to identify how people ... -
Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults
(2021)In this Specialty Grand Challenge, we outline our vision of the current challenges in the field of Network Physiology as applied to aging and frailty. An expected development in this field for the 21st century is the ... -
Sleep habits in older adults in Ireland: Associations with physical and cognitive function
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2021)Sleep acts as the rest cycle for the body, during which restorative processes such as muscle growth, repair and memory consolidation occur. Sleep duration and chronotype have been identified as areas of interest to improve ... -
Nursing homes during the COVID-19 pandemic: a scoping review of challenges and responses
(2021)Introduction: COVID-19 has caused unprecedented challenges in nursing homes. In this scoping review, we aimed to describe factors that contributed to the spread and mortality of COVID-19 in nursing homes and provide an ... -
A mixed-methods feasibility study of a sit-to-stand based exercise programme to maintain knee-extension muscle strength for older patients during hospitalisation
(2021)Objectives: To determine the acceptability of an exercise programme and to identify barriers and facilitators to compliance with the programme from the participants’ perspective. Methods: Patients ... -
Investigating the Implementation of a National Pilot Project on Wait List Management using Pooled Inpatient and Day Case Surgical Waiting List between a Level 4 Hospital and a Level 3 Hospital in Ireland: Patient Experiences and Provider Perspectives
(2017)Introduction: We evaluated a national pilot project on wait-list management using pooled in-patient and day case surgical waiting list across two public hospitals in Ireland - a Level 4 Hospital and a Level 3 Hospital 120km ... -
ARMED TO ESCAPE COVID-19: An evaluation of the impact of COVID-19 on a feasibility study to evaluate the effect of a self-management weight, education and exercise programme on pain, weight, and physical function in patients with knee arthritis at the Primary/Secondary interface.
(2021)Evaluation of preliminary data from this feasibility study supports the three- week intervention combining education, exercise and weight management in this patient group even during a pandemic. Based on the results of ... -
Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis
(2021)Background: It has been postulated that metformin could have anti-SARS-CoV-2 action. This raises the hypothesis that people who take metformin may have lower SARS-CoV-2 severity and/or mortality. Objective To conduct a ... -
Eye Tracking Evaluations of Control Populations and Children with Focal Epilepsy
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Eye tracking has emerged as a powerful tool in studying the eye movements of children. Previous eye tracking studies have not examined eye movements of children with focal epilepsy. The aim of this study was to develop a ... -
Health-related quality of life in narcolepsy: A systematic review and meta-analysis
(2021)To date, there has been no systematic analysis of the literature regarding health-related quality of life in narcolepsy. This systematic review aimed to examine the impact of narcolepsy on health-related quality of life, ... -
Examining the Radiation-induced Bystander Effect (RIBE) and its Effect on Metabolism and Inflammation in Gastrointestinal Cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Radiation therapy is a mainstay of treatment for cancer. However, resistance to therapy remains a major clinical problem in rectal and oesophageal cancer, with at best only 27-30% of patients achieving a complete pathological ... -
Cost-effectiveness Analysis of a Pre-exposure Prophylaxis (PrEP) Programme in Ireland
(2021)Objectives: To estimate the cost-effectiveness of introducing a publicly funded pre-exposure prophylaxis (PrEP) program in Ireland. Methods: We constructed a state-transition Markov model. This was a cross-sectional ... -
The Syncope-Falls Index (SYFI): A tool for predicting risk of syncope and complex falls in the older adult based on cumulative health deficits
(2021)Background Syncope is aetiologically diverse and associated with adverse outcomes; in older people, there is clinical overlap with complex falls presentations (i.e. recurrent, unexplained, and/or injurious). Aim To ... -
Study protocol for TILDA COVID-19 survey. Altered lives in a time of crisis: preparing for recovery from the impact of the COVID-19 pandemic on the lives of older adults
(2021)Background: Older adults are the most at-risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and among the most affected by measures put in place to prevent the spread of the virus. While the ... -
The association of geriatric syndromes with hospital outcomes
(2017)BACKGROUND: Frailty, history of dementia (HoD), and acute confusional states (ACS) are common in older patients admitted to hospital. OBJECTIVE: To study the association of frailty (≥6 points in the Clinical Frailty Scale ... -
Association of cognition with functional trajectories in patients admitted to geriatric wards: a retrospective observational study
(2017)Aim: Impaired cognition is common among older patients admitted to acute hospitals, but its association with functional trajectories has not been well studied. Methods: A retrospective observational study was carried ... -
The association between clinical frailty and walking speed in older hospitalised medical patients: a retrospective observational study
(2017)This study aims to further evaluate the use of the clinical frailty scale (CFS) by assessing its correlation with usual walking speed (UWS) in older medical inpatients. Methods Retrospective observational study in an English ...
