School of Medicine: Recent submissions
Now showing items 821-840 of 3444
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The association between cognitive impairment and functional outcome in hospitalised older patients: a systematic review and meta-analysis
(2017)Background: in hospitalised older adults, cognitive impairments are common and may be associated with functional outcomes. Our aim was to systematically review this association.Method: we systematically searched MEDLINE, ... -
Clinical frailty and functional trajectories in hospitalized older adults: a retrospective observational study
(2017)Frailty predicts inpatient mortality and length of stay, but its link to functional trajectories is under-researched. Addenbrooke's Hospital, Cambridge, UK, collects the Clinical Frailty Scale (CFS) within 72 h of admission ... -
Care home residents admitted to hospital through the emergency pathway: characteristics and associations with inpatient mortality
(2018)Background Routinely collected hospital information could help to understand the characteristics and outcomes of care home residents admitted to hospital as an emergency. Methods This retrospective 2-year ser vice evaluation ... -
The Clinical Frailty Scale predicts inpatient mortality in older hospitalised patients with idiopathic Parkinson s disease
(2018)Parkinson’s disease and frailty are both common conditions affecting older people. Little is known regarding the association of the Clinical Frailty Scale with hospital outcomes in idiopathic Parkinson’s disease patients ... -
Clinical frailty is independently associated with non-prescription of anticoagulants in older patients with atrial fibrillation
(2017)Abstract Aim Anticoagulation is underused in older patients with atrial fibrillation(AF). Scoring systems such as CHA2DS2-VASc and HAS-BLED are recommended to guide clinicians in anticoagulation decisions, ... -
Frail-VIG index: a concise frailty evaluation tool for rapid geriatric assessment
(2018)Background:Demographic changes have led to an increase in the number of elderly frail persons and, consequently,systematic geriatric assessment is more important than ever. Frailty Indexes (FI) may be particularly useful ... -
New Horizons in Frailty: the contingent, the existential and the clinical
(2019)In the past decade, frailty research has focused on refinement of biomedical tools and operationalisations, potentially introducing a reductionist approach. This article suggests that a new horizon in frailty lies in a ... -
Longitudinal studies of ageing: from insights to impacts: Commentary to accompany themed collection on longitudinal studies
(2019)‘Time is the best diagnostician’: who has not thought this? In clinical practice, presentations are often subtle and decisions made in the face of a‘snapshot.’ Crystal balls do not exist; yet, insights from longitudinal ... -
Development and validation of an electronic postoperative morbidity score
(2018)Background: Electronic health records are being adopted due to numerous potential benefits. This requires the development of objective metrics to characterize morbidity, comparable to studies performed in centers without ... -
Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in TILDA
(2019)Background: Fried's frailty phenotype is defined by five criteria: exhaustion, unexplained weight loss, weakness, slowness and low physical activity. Prefrailty (PF) meets one or two criteria. PF is of interest as a target ... -
Clinical frailty independently predicts early mortality after ischaemic stroke
(2020)Background: Clinical frailty is an important syndrome for clinical care and research, independently predicting mortality and rates of institutionalisation in a range of medical conditions. However, there has been little ... -
Functional Mobility Trajectories of Hospitalized Older Adults Admitted to the Acute Geriatric Wards: A Retrospective Observational Study in an English University Hospital
(2019)Aim: The mobility trajectories of hospitalized older people are heterogeneous, and there is a need to understand patient groups with similar trajectories. Our aims were to identify mobility trajectories of older patients ... -
Earlier physical therapy input is associated with a reduced length of hospital stay and reduced care needs on discharge in frail older inpatients: an observational study
(2019)Background and purpose: Pressures on hospital bed occupancy in the English National Health Service have focused attention on enhanced service delivery models and methods by which physical therapists might contribute to ... -
Delaying and reversing frailty: a systematic review of primary care interventions
(2019)Background: Recommendations for routine frailty screening in general practice are increasing as frailty prevalence grows. In England, frailty identification became a contractual requirement in 2017. However, there is little ... -
Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: a Meta-analysis
(2020)Introduction: Hydroxychloroquine (HCQ) has been proposed as a SARS-CoV-2 treatment but the frequency of long QT (LQT) during use is unknown. Objective: To conduct a meta-analysis of the frequency of LQT in patients with ... -
Change in skeletal muscle associated with unplanned hospital admissions in adult patients: a systematic review and meta-analysis
(2019)Objectives: The primary objective of the review was to describe change that occurs in skeletal muscle during periods of unplanned hospitalisation in adult patients. The secondary objective was to examine the relationship ... -
Eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA): stability and clinical associations after 4 years
(2021)Previous research cross-sectionally characterised eight morphological systolic blood pres-sure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the IrishLongitudinal Study on Ageing. ... -
Health and social factors associated with a delayed discharge amongst inpatients in acute geriatric wards: A retrospective observational study
(2018)Aim: In the English National Health Service there is an increasing interest in understanding the factors associated with delayed discharges in older hospitalized adults. The present study sought to analyze whether clinical ... -
Impairments in Hemodynamic Responses to Orthostasis Associated with Frailty: Results from The Irish Longitudinal Study on Ageing (TILDA)
(2018)Objectives: To characterize the relationships between orthostatic blood pressure (BP) and heart rate recovery and frailty in an older population. Design: Cross-sectional study. Setting: Two health centers in the Republic ... -
Anticholinergic medications in patients admitted with cognitive impairment and falls (AMiCI). The impact of hospital admission on anticholinergic cognitive medication burden. Results of a multi centre observational study
(2018)What is known and objective: Drugs with anticholinergic properties increase the risk of falls, delirium, chronic cognitive impairment, and mortality and counteract procholinergic medications used in the treatment of dementia. ...
