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dc.contributor.authorMc Manus, Rossen
dc.date.accessioned2012-06-27T12:23:30Z
dc.date.available2012-06-27T12:23:30Z
dc.date.issued2012en
dc.date.submitted2012en
dc.identifier.citationCatherine M Phillips, Emmanuelle Kesse-Guyot, Namanjeet Ahluwalia, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells, Helen M Roche, Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk, Atherosclerosis, 220, 2, 2012, 513-519en
dc.identifier.otherYen
dc.descriptionPUBLISHEDen
dc.description.abstractObjective: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel cardiometabolic risk factor. Whether dietary fat intake modulates MetS risk conferred by elevated C3 concentrations is unknown. Our objective is to investigate the relationship between C3 concentrations and risk of the MetS and its phenotypes, and to further examine whether dietary fat intake modulates these relationships. Methods: Biochemical, dietary and lifestyle measurements were determined in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). Results: Elevated C3 concentrations (> median) were associated with increased risk of impaired insulin sensitivity [OR 1.78, CI 1.34-2.36, P < 0.0001], insulin resistance [OR 1.73, CI 1.31-2.89, P = 0.0001], abdominal obesity [OR 2.15, CI 1.43-3.24, P = 0.0002] and low HDL cholesterol [OR 1.40, CI 1.05-1.86, P = 0.02] compared to low C3 concentrations. Increased MetS risk conferred by elevated C3 concentrations [OR 3.11, 95% CI 2.52-3.82, P < 0.0001] was further accentuated among high dietary fat consumers [OR 4.80, 95% CI 2.77-8.33, P < 0.0001] (particularly of saturated [OR 4.05, 95% CI 2.33-7.05, P < 0.0001] and monounsaturated fat [OR 4.48, 95% CI 2.62-7.56, P < 0.0001]), and smokers [OR 3.83, 95% CI 2.12-6.94, P < 0.0001], however this effect was abolished in abdominally lean individuals [OR 1.46, 95% CI 0.69-3.14, P = 0.33]. Conclusions: Dietary fat (intake and composition), abdominal obesity and smoking modulate the relationship between elevated plasma C3 concentrations and MetS risk.en
dc.description.sponsorshipThis study was supported by the European Commission, Framework Programme 6 17 (LIPGENE): contract number FOOD-CT-2003-505944. The SU.VI.MAX study is registered as NCT00272428 at ClinicalTrials.gov. We thank all participants and authors for their contributions.en
dc.format.extent513-519en
dc.language.isoenen
dc.relation.ispartofseriesAtherosclerosisen
dc.relation.ispartofseries220en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectClinical medicineen
dc.subjectMetabolic syndromeen
dc.subjectcardiovascular risk factorsen
dc.subjectSmokingen
dc.subjectObesityen
dc.titleDietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risken
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rmcmanusen
dc.identifier.rssinternalid75872en
dc.identifier.doihttp://dx.doi.org/10.1016/j.atherosclerosis.2011.11.007en
dc.relation.ecprojectidinfo:eu-repo/grantAgreement/EC/FP7/505944
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeInternational Developmenten
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorGrantNumber505944en
dc.identifier.urihttp://hdl.handle.net/2262/64039


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