Microbiology: Recent submissions
Now showing items 161-180 of 333
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Fibrinogen activates the capture of human plasminogen by staphylococcal fibronectin-binding proteins
(2017)Invasive bacterial pathogens can capture host plasminogen (Plg) and al- low it to form plasmin. This process is of medical importance as surface-bound plas- min promotes bacterial spread by cleaving tissue components and ... -
MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.
(2017)MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of ... -
Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Eukaryotic genomes are organised as the DNA-protein complex, chromatin within the cell nucleus. The fundamental subunit of chromatin is the nucleosome, which comprises 146 base pairs of DNA wrapped around an octamer of ... -
Analysis of the function of the N1 subdomain of MSCRAMMs of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014)The Microbial Surface Component Recognising Adhesive Matrix Molecules (MSCRAMMs) family of cell wall-associated proteins have recently been reclassified based on structure-function analysis. Under this new regime the MSCRAMM ... -
Biomass to biofuel : the engineering of Saccharomyces species for the co-fermentation of cellulose and xylose
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Lignocellulose represents one of the most abundant biomass sources in the world. Its renewable and abundant nature makes it a prime target for use in bioethanol production. The efficient conversion of lignocellulosic biomass ... -
High-throughput investigation of virulence gene regulation by sRNAs in Salmonella Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)This study focused on novel gene regulatory systems in Salmonella enterics serovar Typhimurium, a model gram-negative, bacterial pathogen. The sRNA-mediated control of virulence genes was a particular emphasis. The research ... -
Analysis of the chloramphenicol resistance determinant of plasmid R26
(Trinity College (Dublin, Ireland). Department of Microbiology, 1985)The Inc P-1 plasmid, R2B carries an inducible chloramphenicol resistance determinant, cml. This specifies low level chloramphenicol resistance (30 μg/ml] in Escherichia coli. The mechanism does not involve drug detoxification ... -
Investigating the transcriptional regulation of small RNA expression in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important foodborne pathogen that causes self-limiting gastroenteritis, or more serious systemic infections in susceptible hosts. S. Typhimurium can infect a ... -
The identification of novel peptides using phage display with the potential for use in breast cancer therapy
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Breast cancer is a leading cause of cancer-related mortality in women. Current treatments for breast cancer include surgery, radiotherapy, chemotherapy and hormone therapy. The recent development of Herceptin has added a ... -
The interaction of clumping factor B and iron-regulated surface determinant protein A of Staphylococcus aureus with the squamous epithelial cell envelope protein loricrin
(Trinity College (Dublin, Ireland). Department of Microbiology, 2013)Staphylococcus aureus permanently colonises the anterior nares of 20% of the human population while the remainder is colonised intermittently. Clumping factor B (ClfB) is a surface-expressed staphylococcal protein that ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-borne apicomplexan Plasmodium falcipanim. The lack of an effective vaccine coupled with ... -
Antimicrobial peptide preventing beer spoilage
(Trinity College (Dublin, Ireland). Department of Microbiology, 2012)Beer spoilage micro-organisms (BSMs) are a common threat to Master Brewers worldwide. Numerous studies have been carried out to date to overcome this problem, yet the most common preventative measure is the addition of ... -
Construction and development of simliki forest virus vectors for transient gene therapy of model tumours in mice
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Cancer is a molecular and genetic disease that results from multiple alterations of genes, including proto-oncogenes and tumour-suppressor genes. Virotherapy is a branch of cancer gene therapy where oncolytic viruses are ... -
Biomass to biofuel : towards the bioengineering of Saccharomyces species for cellulose degradation
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Cellulose is the most abundant polysaccharide on earth and therefore represents a major reservoir of sugar that could be potentially converted to alcohol and used as a fuel source. The filamentous fungus Trichoderma reesei ... -
Fibronectin-binding protein B variation in straphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)The surface-expressed fibronectin-binding proteins FnBPA and FnBPB of Staphylococcus aureus mediate attachment to immobilised fibronectin, fibrinogen and elastin. These proteins are encoded by two closely linked but ... -
Identification of factors involved in 3' end processing and transcription termination of histone mRNAs
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)The production of core histone mRNAs is tightly regulated during the cell cycle in all eukaryotic cells. Histone mRNAs accumulate during the S-phase and are subsequently degraded upon entry into G2-phase of the cell cycle. ...
