Microbiology: Recent submissions
Now showing items 181-200 of 333
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Investigation of herbicide-based compounds as novel anti-malarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Plasmodium falciparum causes the most severe form of malaria in humans. Currently, no effective vaccine exists and the emergence of widespread drug resistance in the parasite has further increased the necessity for novel ... -
Biasing switching outcomes in the Escherichia coli fim site-specific recombination system through DNA supercoiling and nucleoid-associated proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Type 1 fimbriae are typically expressed in nutrient poor environments and facilitate colonization through attachment when the bacterium can no longer support a motile lifestyle that demands a high metabolic flux. They play ... -
Mechanical strength and inhibition of the Staphylococcus aureus collagen-binding protein Cna
(2016)The bacterial pathogen Staphylococcus aureus expresses a variety of cell surface adhesion proteins that bind to host extracellular matrix proteins. Among these, the collagen (Cn)-binding protein Cna plays important roles ... -
Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.
(2016)Staphylococcus aureus is a commensal bacterium that has the ability to cause superficial and deep-seated infections. Like several other invasive pathogens, S. aureus can capture plasminogen from the human host where it can ... -
Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation
(2016)Staphylococcus lugdunensis is a coagulase negative bacterial pathogen that is particularly associated with severe cases of infectious endocarditis. Unique amongst the coagulase-negative staphylococci, S. lugdunensis harbors ... -
Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds.
(2015)Staphylococcus aureus is an important opportunistic pathogen which is a leading cause of biofilm-associated infections on indwelling medical devices. The cell surface-located fibronectin-binding protein A (FnBPA) plays an ... -
Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation.
(2015)Staphylococcus aureus biofilms, a leading cause of persistent infections, are highly resistant to immune defenses and antimicrobial therapies. In the present study, we investigated the contribution of fibrin and staphylokinase ... -
Engineering Saccharomyces pastorianus for the co-utilisation of xylose and cellulose from biomass.
(2015)Background Lignocellulosic biomass is a viable source of renewable energy for bioethanol production. For the efficient conversion of biomass into bioethanol, it is essential that sugars from both the cellulose and ... -
Structure-function analyses of the interactions between Rab11 and Rab14 small GTPases with their shared effector Rab coupling protein (RCP)
(2015)Rab GTPases recruit effector proteins, via their GTP-dependent switch regions, to distinct subcellular compartments. Rab11 and Rab25 are closely related small GTPases that bind to common effectors termed the Rab11 family ... -
Studies of Streptococcus pneumoniae colonisation : role of capsule and induction of protective immunity
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for an estimated 1.6 million deaths each year, most of which are of young children in the developing world. Current pneumococcal vaccines ... -
Epidemiology of Streptococcus agalactiae (Group B Streptococci) in Dublin Maternity Hospitals
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Streptococcus agalactiae (Group B Streptococci) are Gram-positive encapsulated cocci distinguished from other streptococci by their narrower zones of P-haemolysis. Group B Streptococci (GBS) was first described as an ... -
Re-engineering cellular physiology by rewiring high-level global regulatory genes
(2015)Knowledge of global regulatory networks has been exploited to rewire the gene control programmes of the model bacterium Salmonella enterica serovar Typhimurium. The product is an organism with competitive fitness that is ... -
Investigation of the transcriptional landscape and RNA biology of Salmonella Typhimurium plasmids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014) -
Fibronectin binding proteins are required for biofilm formation by community-associated methicillin resistant Staphylococcus aureus strain LAC
(2014)Community-associated methicillin-resistant Staphylococcus aureus of the USA300 lineage is emerging as an important cause of medical device-related infection. However, few factors required for biofilm accumulation by USA300 ... -
Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion
(2015)The purpose of this study was to investigate the blood stage of the malaria causing parasite, Plasmodium falciparum, to predict potential protein interactions between the parasite merozoite and the host erythrocyte and ... -
Immunophilin-protein interactions in Plasmodium falciparum.
(2015)Immunophilins comprise two protein families, cyclophilins (CYPs) and FK506-binding proteins (FKBPs), and are the major receptors for the immunosuppressive drugs cyclosporin A (CsA) and FK506 (tacrolimus), respectively. ... -
Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution
(2015)Antimalarial chemotherapy continues to be challenging in view of the emergence of drug resistance, especially artemisinin resistance in Southeast Asia. It is critical that we identify novel anti-malarial drugs that inhibit ... -
Deletion of the nuclear exosome component RRP6 leads to continued accumulation of the histone mRNA HTB1 in S-phase of the cell cycle in Saccharomyces cerevisiae.
(2007)The nuclear exosome, a macromolecular complex of 3 ’ to 5 ’ exonucleases, is required for the post- transcriptional processing of a variety of RNAs including rRNAs and snoRNAs. Additionally, this complex forms part ...
