Microbiology: Recent submissions
Now showing items 81-100 of 333
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Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A.
(2005)Staphylococcus aureus is an important cause of infective endocarditis (IE) in patients without a history of prior heart valve damage. The ability to stimulate the activation of resting platelets and their subsequent ... -
Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG
(2016)Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical ... -
The binding of calcium to the B-repeat segment of SdrD, a cell surface protein of Staphylococcus aureus
(1998)In the Sdr family of Staphylococcus aureus cell surface proteins, three recently cloned members (Josefsson, E., McCrea, K., Ni Eidhin, D., O'Connell, D., Cox, J. A., Hook, M., and Foster, T. (1998) Microbiology, in press) ... -
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
(2017)Staphylococcus aureus is frequently isolated from the skin of atopic dermatitis (AD) patients during flares. The normal microbiota is disrupted and the diversity of the microorganisms on the skin is reduced. Many species ... -
Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection
(2010)Background. Staphylokinase (SAK) is produced by the majority of Staphylococcus aureus strains. It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in ... -
Design and characterisation of food grade powders and inks for microstructure control using 3D printing
(2018)Additive Manufacturing techniques have been previously applied to food materials with direct consumption in mind, as opposed to creating structural ingredients as shown in this study. First, semi-crystalline cellulose was ... -
The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site.
(2011)The fibronectin‐binding proteins FnBPA and FnBPB are multifunctional adhesins than can also bind to fibrinogen and elastin. In this study, the N2N3 subdomains of region A of FnBPB were shown to bind fibrinogen with a similar ... -
The dipeptide repeat region of the fibrinogen-binding protein (clumping factor) is required for functional expression of the fibrinogen-binding domain on the Staphylococcus aureus cell surface.
(1997)Clumping factor of Staphylococcus aureus is a fibrinogen‐binding protein that is located on the bacterial cell surface. The protein has an unusual repeat domain (region R) comprising mainly the dipeptide aspartate and ... -
Involvement of the accessory gene regulator (agr) in expression of type 5 capsular polysaccharide by Staphylococcus aureus
(1993)The effect of an agr mutation on expression of type 5 capsular polysaccharide (CP) by Staphylococcus aureus Newman was investigated in different complex and synthetic media. CP expression by the agr mutant was strongly ... -
Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
(2015)Staphylococcus aureus necrotizing pneumonia is recognized as a toxin-mediated disease, yet the tissue-destructive events remain elusive, partly as a result of lack of mechanistic studies in human lung tissue. In this study, ... -
Fluid Gels: a New Feedstock for High Viscosity Jetting
(2018)Suspensions of gel particles which are pourable or spoonable at room temperature can be created by shearing a gelling biopolymer through its gelation (thermal or ion mediated) rather than allowing quiescent cooling – thus ... -
Investigating chromatin remodelling by the Swi-Snf and Tup1-Cyc8 complexes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)Swi-Snf is an ATP-dependent chromatin remodelling complex which generally acts as a co-activator of gene transcription via its removal of promoter nucleosomes. Conversely, Tup1-Cyc8 (Ssn6) is a co-repressor complex which ... -
Unravelling a food derived bioactive peptide with dual functionality of antimicrobial and immunomodulatory properties
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)In this thesis, a computational data mining and feature based approach to unravel the abundance of unexplored peptides from nature and to identify potent, novel antimicrobial peptides (AMPs) from phyto-proteins is proposed. ... -
Broad scale redistribution of mRNA abundance and transcriptional machinery in response to growth rate in Salmonella enterica serovar Typhimurium
(2017)We have investigated the connection between the four-dimensional architecture of the bacterial nucleoid and the organism's global gene expression programme. By localizing the transcription machinery and the transcriptional ... -
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium
(2017)Indirect readout mechanisms of transcription control rely on the recognition of DNA shape by transcription factors (TFs). TFs may also employ a direct readout mechanism that involves the reading of the base sequence in the ... -
When is a transcription factor a NAP?
(2020)Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins ... -
Consequences of exchanging the NAP-encoding genes fis and dps in Salmonella enterica Serovar Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)The genes encoding nucleoid associated proteins (NAPs) are syntenic among γ-Proteobacteria, and several factors are known to impact gene expression at a given locus, including changes in gene dosage caused by DNA replication. ... -
Regulatory hierarchies controlling virulence gene expression in Shigella flexneri and Vibrio cholerae
(2018)Gram-negative enteropathogenic bacteria use a variety of strategies to cause disease in the human host and gene regulation in some form is typically a part of the strategy. This article will compare the toxin-based infection ... -
The hybrid genomes of Saccharomyces pastorianus-a current perspective
(2018)Saccharomyces pastorianus is a recently evolved interspecies hybrid of Saccharomyces cerevisiae and Saccharomyces eubayanus used in the production of lager-type beers and has a long-standing history with the brewing industry. ... -
Staphylococcus aureus superantigen-like protein SSL1: A toxic protease
(2019)Staphylococcus aureus is a major cause of corneal infections that can cause reduced vision, even blindness. Secreted toxins cause tissue damage and inflammation resulting in scars that lead to vision loss. Identifying ...
