Clinical Medicine: Recent submissions
Now showing items 101-120 of 1003
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Novel Mechanisms of Resistance to Enzalutamide in Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Prostate cancer (PCa) is the second most common invasive cancer in men worldwide. In Ireland, PCa is the third leading cause of male cancer related mortality. AR directed therapies have remained the primary therapeutic ... -
An Analysis of the Biopsychosocial Factors including Sex and Pregnancy in Women with Axial Spondyloarthritis; Data from the Ankylosing Spondylitis Registry of Ireland (ASRI)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With advances in pathophysiology, development of novel classification criteria and the advent of new therapeutic agents the field of axial spondyloarthritis (axSpA) is rapidly evolving. Despite this, the impact and interplay ... -
Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA) Student: Patrick O?Donoghue ... -
The Impact of Socio-Demographic and Clinical Factors on Acute Medical Service Utilisation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Socio-economic status impacts health throughout the lifecycle. It does this by affecting income, accommodation, access to education and skills, and access to healthcare. This mediates the phenotypic expression of disease ... -
Optimising the In-Hospital Management of Hip Fracture Using the Irish Hip Fracture Database
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hip fracture can have a devastating impact on older adults as it is associated with reduced life expectancy, loss of independence and poorer quality of life. Each year in Ireland approximately 3,600 patients experience a ... -
Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
Physical function in community-dwelling older adults - a focus on health inequality and ageing in place
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis sought to explore socioeconomic determinants of physical function in community-dwelling older adults, with implications for ageing in place. While several markers of physical function are explored in this thesis, ... -
Radioiodine Dosimetry for Benign and Malignant Thyroid Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Thyroid diseases are a common clinical disorder with 5-10% diagnosed as thyroid cancer. The published guidelines that provide clinical guidance for the diagnosis, treatment and management of thyroid diseases, based on a ... -
The frail brain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background and aims: Frailty in older adults has been associated with reduced brain health and greater risk of cognitive decline. However, structural and functional brain signatures of frailty remain understudied, with ... -
Mucosal Associated Invariant T Cells and Insulin Resistance in Hidradenitis Suppurativa
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterised by recurrent painful nodules, abscesses and draining sinus tracts. There is a paucity of effective treatments and it severely impairs ... -
The Pathological Associations of Hyperuricaemia in Sub-Clinical Gout, Cardiovascular and Cardiopulmonary Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Abstract - Introduction Gout is a common and treatable disease caused by the deposition of MSU crystals in articular and non-articular structures. Hyperuricaemia is the most important risk factor for the development of ... -
Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma: Genetic Aberrations Associated with Local and Distant Recurrence
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction HPV driven OPSCC proffers a more favourable prognosis in contrast to its HPV negative counterparts. Consequently, studies have analysed de-intensification measures of current treatment practices to minimise ... -
Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study
(2023)Survival prediction is integral to oncology and palliative care, yet robust prognostic models remain elusive. We assessed the feasibility of combining actigraphy, sleep diary data, and routine clinical parameters to ... -
Predictive Microbiome Post-Bone Marrow Transplantation and Acute Graft versus Host Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemopoietic stem-cell transplantation serves as one of the life-saving options for the management of refractory haematological malignancies and rarely for non-malignant conditions. The era of transplantation has significantly ... -
Cerebral changes in Poliomyelitis survivors: A computational neuroimaging study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Post-polio syndrome (PPS) is a slowly progressive LMN condition that affects 20-85% of polio survivors many decades after their initial acute infection. While motor dysfunction is the hallmark of the disease, extra-motor ... -
A Cost-effectiveness Analysis of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Screening in an Emergency Department in Ireland.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Background: The acceptability and utility of screening for HIV, HBV, and HCV in the ED has been demonstrated. Previous studies have reported cost-effectiveness of screening for either HIV mono-infection or HBV/HCV co-infection ... -
Clinically-assisted hydration in patients in the last days of life (?CHELSEA II? trial): a cluster randomised trial
(2022)Introduction Provision of clinically assisted hydration (CAH) at the end of life is one of the most contentious issues in medicine. The aim of the ‘CHELsea II’ trial is to evaluate CAH in patients in the last days of life. ... -
Development of SIRT1 siRNA-carrying liposomes for treatment of prostate cancer
(2020)Sirtuin 1 (SIRT1) is a histone deacetylase (HDAC) from Sirtuin family and high expression of it induces activation of DNA repairing factors eventually leading either tumor suppression or tumor development in cellular ... -
Evaluation of the effect of solid and cationic lipids on siRNA delivery systems
(2020)This study aims to develop nanoparticles with different types of solid and cationic lipids and evaluate them as siRNA delivery systems. For this purpose, we prepared a series of lipid nanoparticles by combining cationic ...
