Clinical Medicine: Recent submissions
Now showing items 121-140 of 1003
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A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability
(2020)We aimed to develop nanostructured lipid carriers (NLCs) displaying similar characteristics – particle size, polydispersity index, and zeta potential – with the model solid lipid nanoparticles (SLNs) for better comparability. ... -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
(2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Implementation of 26 Gy in five fractions over 1 week adjuvant radiotherapy for breast cancer: Prospective report of acute skin toxicity and consideration of resource implications
(2023)Purpose: In March 2020, a 1-week adjuvant breast radiotherapy schedule, 26 Gy in 5 fractions, was adopted to reduce the risk of COVID19 for staff and patients. This study quantifies acute toxicity rates and the effect ... -
Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient?s Perspective
(2022)Background Colon Capsule Endoscopy (CCE) has proven efficacy in a variety of gastrointestinal diseases. Few studies have assessed patient-reported outcomes and preference between colonoscopy and CCE. Methods Patients ... -
Single or double headed capsules for the investigation of suspected small bowel bleeding: Are two heads better than one.
(2022)Background: Capsule endoscopy is now the accepted first line investigation for suspected small bowel (SB) bleeding. Recent evidence suggests the diagnostic yield for SB pathology may be higher for tailored double headed ... -
NRF2 in liver injury and repair: its relevance to liver transplantation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Liver transplantation is the only effective curative treatment for end-stage liver disease and modern-day practice has led to excellent survival outcomes. Ensuring access to suitable allografts remains crucial as patients ... -
Towards Closing the Care Gap in Bone Health in Gynaecological Oncology
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Loss of bone mineral density (BMD) resulting in osteopaenia, or osteoporosis is relatively common in women, particularly postmenopausal women. Women with gynaecological malignancies are at particular risk due to the effect ... -
Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
(2023)This Guideline is an official statement from the European Society of Gastrointestinal Endoscopy (ESGE). It is an update of the previously published 2015 ESGE Clinical Guideline addressing the role of small-bowel ... -
Key research questions for implementation of artificial intelligence in capsule endoscopy.
(2022)Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with ... -
L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner
(2022)Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour ... -
Oral symptom assessment tools in patients with advanced cancer: a scoping review
(2022)Purpose: Oral symptoms are common in patients with advanced cancer. The aim of this scoping review was to identify oral symptom assessment tools that have been specifically utilised in patients with "advanced cancer". Methods: ... -
MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer
(2022)Purpose: The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer
(2022)Purpose: The pro vision of clinically assisted nutrition (CAN) in patients with advanced cancer is controversial, and there is a paucity of specific guidance, and so a diversity in clinical practice. Consequently, the ... -
Palliative care in the era of novel oncological interventions: needs some �tweaking�
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ... -
A prospective, real-world, multinational study of naloxegol for patients with cancer pain diagnosed with opioid-induced constipation - the NACASY Study
(2022)The Naloxegol Cancer Study (NACASY) was a multinational European study aimed to evaluate the 4-week safety and efficacy of naloxegol in a real-world setting in patients with cancer pain diagnosed with opioid-induced ... -
Stand Up, Speak Out! Racial Justice in Healthcare Education: Experiences of Minoritised Ethnic Students
(TCD, 2022)Funded by Trinity Equality Fund 2022, the Faculty of Health Sciences Equality, Diversity and Inclusion (EDI) Group and Immigrant Council of Ireland launched a project entitled ‘Stand Up, Speak Out! Racial Justice in ... -
Mental Disorders in Older Adults Admitted to General Hospitals: Review of Patient, Service Provision and Environmental Factors
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)The prevalence of mental illnesses in older general hospital inpatients has been studied widely however data from the Irish population is lacking. Psychiatry of Old Age Liaison (`POA Liaison¿) services provide assessment ... -
Investigation of retinal thickness using optical coherence tomography: a prospective phenotype study of patients with inherited ataxia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Inherited cerebellar ataxias (CA) are clinically and genetically heterogeneous disorders. A diverse range of ophthalmic abnormalities have been reported in different subtypes of CA and, although visual symptoms are not ... -
Consensus for experimental design in electromyography (CEDE) project: Terminology matrix
(2021)Consensus on the definition of common terms in electromyography (EMG) research promotes consistency in the EMG literature and facilitates the integration of research across the field. This paper presents a matrix developed ... -
Prospective Study of a Novel Diagnostic Algorithm for Investigating and Managing Gastrointestinal Disease Through The Appropriate Use of Biomarkers and Wireless Based Capsule Endoscopy
This chapter gives a general outline of the thesis for better understanding of issues surrounding research areas and studies that have been performed. Lower Gastrointestinal (GI) Symptoms are common and often warrant further ...
