Clinical Medicine: Recent submissions
Now showing items 201-220 of 1003
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Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis
(2018)Current therapies for treating antineutrophil cytoplasm autoantibody (ANCA)–associated vasculitis include cyclophosphamide and corticosteroids. Unfortunately, these agents are associated with severe adverse effects, despite ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.
(2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient
(2021)The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current advisory guidelines for high-risk groups—including people with autoimmune disease ... -
Human Poxvirus protein MC132 from Molluscum Contagiosum Virus inhibits NF-κB activation by targeting p65 for degradation.
(2015)Molluscum contagiosum virus (MCV) is unique in being the only known extant, human-adapted poxvirus, yet to date, it is very poorly characterized in terms of host-pathogen interactions. MCV causes persistent skin lesions ... -
Poxviral Targeting of Interferon Regulatory Factor Activation.
(2020)As viruses have a capacity to rapidly evolve and continually alter the coding of their protein repertoires, host cells have evolved pathways to sense viruses through the one invariable feature common to all these pathogens—their ... -
Human Neurodegeneration: A Spectral EEG and TMS based Approach in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic lateral sclerosis (ALS) is defined by the neurodegeneration of upper and lower motor neurons of the corticospinal tract, resulting in progressive, terminal and incurable decline in movement, speech and swallowing ... -
The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Title : The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding. Author: Dr ... -
Development of an Objective Assessment of the Cognitive, Posturographic, and Electrophysiological Phenotype of the Fragile X Premutation, and analysis of their contribution to Postural Instability.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The Fragile X Premutation is a complex genetic anomaly which affects one in 260 females and 400 males and results in a broad range of symptoms and distinct conditions. The premutation phenotype involves cognitive and motor ... -
The implementation of a collaborative peer learning 2:1 model of practice placement education within dietetics pre-registration training in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The educational approach towards practice education in health-related disciplines has changed in recent years. The use of collaborative peer learning models of practice education has increased, associated with positive ... -
CO-MORBIDITIES OF HIDRADENITIS SUPPURATIVA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Hidradenitis suppurativa (HS), is a chronic inflammatory skin disorder which can have debilitating consequences if not managed appropriately from early on of its course of disease. Patients with this condition, also ... -
Characterisation of the role of IL-18 in neovascular AMD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Age-related macular degeneration is the leading cause of vision loss in the over 50’s in developed countries, accounting for 8.7% of all blindness worldwide. AMD is a progressive disease affecting the macula region of the ... -
Steroid resistance and Inflammatory bowel disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Background: Steroid resistance remains a significant issue amongst IBD patients and mechanisms of resistance remain poorly understood. Endogenous Glucocorticoid metabolism may represent a key regulatory pathway in IBD. ... -
Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes
(2020)Carbon‐based nanomaterials (C‐BNM) have recently attracted an increased attention as the materials with potential applications in industry and medicine. Bioresistance and proinflammatory potential of C‐BNM is the main ... -
A complex morphofunctional approach for zinc toxicity evaluation in rats
(2020)Anthropogenic activity causes the introduction of zinc compounds into the biological cycle in mining and processing sites and its accumulation in organs and tissues, causing systemic toxicity. A cumulative effect of zinc ... -
In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective.
(2020)When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation. Inhalation is a major exposure route for humans, and the respiratory ... -
Preclinical Development of Orally Inhaled Drugs (OIDs)-Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?
(2020)Respiratory diseases constitute a huge burden in our society, and the global respiratory drug market currently grows at an annual rate between 4% and 6%. Inhalation is the preferred administration method for treating ... -
Risk management framework for nano-biomaterials used in medical devices and advanced therapy medicinal products
(2020)The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns ... -
Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
(2020)Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials ... -
Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer
(2020)Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation and are believed to represent a fingerprint of the releasing cell. We isolated and characterized serum EVs of breast tumour-bearing animals, ... -
Nanotechnology in pulmonary medicine
(2021)Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to ...
