Clinical Medicine: Recent submissions
Now showing items 181-200 of 1003
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Colon capsule endoscopy is a viable alternative to colonoscopy for the investigation of intermediate- and low-risk patients with gastrointestinal symptoms: results of a pilot study
(2021)Background and study aims: Colon capsule endoscopy (CCE) is a recommended viable alternative to colonoscopy for colonic visualisation in a variety of clinical settings with proven efficacy in polyp detection, surveillance, ... -
Three-dimensional (3D) hepatic cell culture models to improve the clinical translation of nanobiomaterials (NBMs)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Despite the wide-reaching applications of nanoparticles that may be used for medical applications, i.e. nanobiomaterials or NBMs, in human health and medicine, their translation to the clinic is staggering slow, with a ... -
ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients
(2019)Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the third leading cause of death worldwide. Recent reports have indicated that dysfunctional iron handling in the lungs of COPD ... -
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
(2019)The prevalence of obesity is rising worldwide, and obese patients constitute a specific population in the intensive care unit. Acute respiratory distress syndrome (ARDS) incidence is increased in obese patients. Exposure ... -
Mitochondrial Iron in Human Health and Disease
(2019)Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria encompass an active organellar network that fuses, divides, and directs a myriad of vital biological functions, including energy metabolism, ... -
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
(2019)Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type 2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis. However, the role of mitochondrial ... -
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort
(2020)BACKGROUND: Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly ... -
Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
(2021)Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate ... -
Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease
(2020)Metabolic plasticity involving shifts between mitochondrial respiration and glycolysis is emerging as a crucial component of innate immune cell function. The number of alveolar macrophages (AMs), the most abundant ... -
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
(2020)Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but theimportance and regulation of these changes remain unclear. We found that hepcidin, themaster regulator of systemic iron homeostasis, ... -
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
(2020)Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage fluid of individuals with chronic obstructive pulmonary disease (COPD), when compared to healthy controls. Whether more ... -
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort
(2021)Background: There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release ... -
Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2
(2021)Determining the layers of gene regulation within the innate immune response is critical to our understanding of the cellular responses to infection and dysregulation in disease. We identified a conserved mechanism of gene ... -
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study
(2021)Introduction:Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), butthe effect of frailty has been unclear.Methods:This multi-centre cohort study involved patients aged 18 ... -
Making healthcare accessible for single adults with complex needs experiencing long-term homelessness: A realist evaluation protocol
(2021)Background: Over the last several years, homelessness has increased in Ireland and across Europe. Rates have recently declined since the coronavirus disease 2019 (COVID-19) pandemic, but it is unclear whether emergency ... -
Improving access to epilepsy care for homeless patients in the Dublin Inner City: a collaborative quality improvement project joining hospital and community care
(2021)Homelessness is associated with significant psychosocial and health disparities. The rate of epilepsy among this cohort is eight times greater than that in the settled population, and the associated morbidity is higher due ... -
Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial cell activation
(2021)Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonarymicrovascular occlusion, which is a hallmark of severe coronavirus disease 2019(COVID-19). Consistent with EC activation, increased plasma ... -
Eye Tracking Evaluations of Control Populations and Children with Focal Epilepsy
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Eye tracking has emerged as a powerful tool in studying the eye movements of children. Previous eye tracking studies have not examined eye movements of children with focal epilepsy. The aim of this study was to develop a ... -
Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis
(2017)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility ...
