Clinical Medicine: Recent submissions
Now showing items 241-260 of 1003
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Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
(2020)Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils and monocytes. While the role of neutrophils ... -
An examination of the neuroimmune interactions of amitriptyline, spinal cord stimulation and opioid therapy in human neuropathic pain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Background: The objective of this thesis was to explore mechanistic processes of amitriptyline, opioids and "Burst" spinal cord stimulation (SCS) for neuropathic pain in vivo. These three therapies are commonly employed ... -
Personalised Medicine in ANCA-Associated Vasculitis: The Role of Urine Soluble CD163
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)In this thesis I have identified a highly sensitive and specific association between urinary sCD163 and active renal vasculitis in the clinical setting of renal vasculitis flare in both retrospective and prospective studies. ... -
Clinical and Demographic Features of Voluntary and Involuntary Admissions under Ireland's Mental Health Act, 2001: The Dublin Involuntary Admission Study (DIAS), 2008-2018
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Involuntary admission and treatment are common, long-standing features of psychiatry but the relationships between diagnosis, demographic factors and other elements of involuntary treatment are not clear. Involuntary ... -
Characterisation of the efficacy of two novel host-directed therapies, SCD-19 and 4-octyl itaconate, for the treatment of Pseudomonas aeruginosa infection in cystic fibrosis.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Cystic Fibrosis (CF) is a life limiting genetic disease, which is caused by genetic mutations which result in defective function of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In CF, patients experience ... -
A Precision Medicine Approach to Dosing and Management of Continuous Renal Replacement Therapy for Acute Kidney Injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Despite decades of research, the mainstay of treatment for severe acute kidney injury (AKI) in the critical care setting remains renal replacement therapy in the form of dialysis. Continuous renal replacement ... -
Can the systematic use of non-invasive biomarkers in patients with lower gastrointestional sysmtpoms help rationalise the demand for limited endoscopy resources?
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Introduction: Gastrointestinal complaints are very common in the general population. Demand for endoscopy continues to outstrip capacity, despite significant annual increase in the number of endoscopies performed nationwide, ... -
Acute Stroke Care in Ireland - The Role of a National Audit in Improving Care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: The 2008 Irish national audit of stroke service (INASC) showed large deficits in service provision and access. A national stroke programme emerged to develop services and address these deficits. The country ... -
Development of significant disease in a cohort of patients with non-specific enteritis on capsule endoscopy: clinical suspicion and a high base line Lewis score are predictive of Crohn's disease.
(2020)Background: As with isolated ileitis the findings of nonspecific small bowel enteritis (NSE) on capsule endoscopy (CE) poses a clinical challenge. There is lack of available evidence to help clinicians to predict significant ... -
A Longitudinal Study of the Evolution of Neuropsychological Change in Amyotrophic Lateral Sclerosis: The Incidence, Nature and Progression of Language Impairment.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Amyotrophic Lateral Sclerosis is a multi-system disease that also affects cognition and behaviour. Cognitive change in ALS manifests most commonly as executive dysfunction. Although changes in language function ... -
Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review.
(2020)Background: Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare multi-system autoimmune disease, characterised by a pauci-immune necrotising small-vessel vasculitis, with a relapsing and remitting ... -
The impact of folate and vitamin B12 intake and biomarker status on cognitive performance in older adults on the island of Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Some studies have reported that suboptimal B vitamin status has been negatively associated with cognition in older adults, though, not all studies have observed this. This is hampered by the lack of new and ... -
Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study
(2020)BACKGROUND Neovascularisation is common to a variety of gastrointestinal (GI) disorders with differing aetiologies and presentations; usually affecting adults above 60 years. Shared angiogenic factors modulated by disease ... -
Diffusion Weighted and Diffusion Tensor MRI-derived Apparent Diffusion Coefficient and Fractional Anisotropy Values as Biomarkers for Treatment Response in Breast Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background With increasing numbers of patients receiving neoadjuvant chemotherapy (NACT) for breast cancer and with multiple emerging drug agents, a reliable indicator of treatment response early in the course of ... -
A study of the clinical impact and outcomes of pharmacist-led interventions in the outpatient model of care for Hepatitis C patients in Ireland and their development into a novel complex intervention toolkit
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Given the high rates of sustained virological response and good tolerability of direct-acting antiviral regimens, international guidelines now recommend that all Hepatitis C infected patients be considered for access to ... -
Profiles of von Willebrand factor antigen, von Willebrand factor propeptide and ADAMTS13 activity in patients with ischaemic cerebrovascular disease after commencing or changing antiplatelet therapy
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: There are very limited data on the impact of commonly-prescribed antiplatelet regimens on von Willebrand Factor antigen (VWF:Ag), von Willebrand Factor propeptide (VWFpp) and A Disintegrin And Metalloprotease ... -
Troponin status predicts 30-day in-hospital mortality
(2020)Aim: To evaluate the prognostic value of high-sensitivity cardiac troponin (hscTnT) levels in unselected emergency medical admissions. Methods: We report on all hscTnT tests in emergency medical admissions, ... -
Cancer Cachexia - Prevalence and Predictors in Treatment-naive Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Title: Cancer Cachexia Prevalence and Predictors in Treatment-naïve Patients Candidate Name: Dr Niamh O Donoghue Background Cancer cachexia is a common wasting syndrome, yet it remains poorly understood and under-recognised. ... -
Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood monocytes differentiate into the dichotomous M1 ... -
Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Gastroesophageal junction adenocarcinomas (GEJA) have increased in incidence in the Western world over the last 50 years, a trend largely attributed to lifestyle factors including obesity and gastroesophageal reflux disease. ...
