Clinical Medicine: Recent submissions
Now showing items 261-280 of 1003
-
A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Study background: The introduction and availability of highly active antiretroviral therapy (HAART) led to an increased life expectancy among people living with HIV (PLWH) and reduced the incidence of HIV associated dementia ... -
IL-1 family members in health and disease
(2019)In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family – IL-1α and IL-1β. These potent pro-inflammatory cytokines ... -
Investigation into the Pathophysiology and the Objective Neurophysiological Measurement of Cancer-Related Fatigue in a Pre-Treatment Cancer Cohort
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Cancer-related fatigue (CRF) is one of the most common, debilitating, highly prevalent and unrelenting symptom experienced by patients through all stages of the cancer trajectory and often into survivorship (Berger et al., ... -
Molecular Evaluation of Enzalutamide Resistance in Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Prostate cancer is a leading cause of cancer related death in men. As prostate cancer cells are dependent on androgen receptor (AR) signalling for continued growth, anti-androgen therapy is initially effective in treating ... -
Lower gastrointestinal symptoms and symptoms-based triaging systems are poor predictors of clinical significant disease on colonoscopy.
(2020)Introduction: Lower gastrointestinal symptoms (LGS) are a common cause of referral to the gastroenterology service. International guidelines are available to prioritise referrals. Some studies have reported that symptoms ... -
The spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management
(2020)Impulse control behaviours (ICBs) are a range of behaviours linked by their reward-based, repetitive natures. They can be precipitated in Parkinson’s Disease (PD) by dopamine replacement therapy, often with detrimental ... -
Profiles of von Willebrand factor antigen, von Willebrand factor propeptide and ADAMTS13 activity in patients with carotid stenosis and their relationship with cerebral micro-embolic signal status
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Aims: The aims of this thesis were to comprehensively investigate the profiles of von Willebrand Factor (VWF:Ag), von Willebrand Factor propeptide (VWFpp) and A Disintegrin And Metalloprotease with ... -
Platelet activation status, on-treatment platelet reactivity and reticulated platelets in the early and late phases after TIA/ischaemic stroke
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Aims: This thesis aimed to assess platelet activation status, on-treatment platelet reactivity and the profile of reticulated platelets in patients with ischaemic cerebrovascular disease (CVD) who were commencing or changing ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
(2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
(2020)Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials ... -
KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment
(2019)KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects of cancer cell biology: inflammation and cell-fate determination. However, the role KHSRP plays in ... -
Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett?s esophagus compared to esophageal adenocarcinoma
(2019)Barrett’s esophagus (BE), a chronic inflammatory condition, is the leading risk factor for esophageal adenocarcinoma (EAC). In inflammation to cancer pathways, oxidative stress profiles have been linked to cancer progression. ... -
Vitamin D in the elderly and its relationship to inflammation and cognitive health
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: There is a major shift in ageing demographics as individuals are experiencing increased longevity. This shift may be beneficial for the individual who will live into more advanced year than their ancestors. ... -
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF?B and Autophagy Dependent Bacillary Killing
(2016)The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has increased the urgency to develop novel treatment modalities, ... -
Validation of two risk prediction models for recurrent falls in the first year after stroke: A prospective cohort study
(2017)Background: several multivariable models have been derived to predict post-stroke falls. These require validation before integration into clinical practice. The aim of this study was to externally validate two prediction ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
INFLAMMATORY DENDRITIC CELLS IN THE HOST IMMUNE RESPONSE TO MYCOBACTERIA: THE ROLE OF CELLULAR METABOLISM
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Mycobacterium tuberculosis (Mtb) causes an estimated 1.5 million deaths annually and BCG, the only available vaccine, is ineffective at preventing adult pulmonary TB. Inflammatory dendritic cells (DCs) play an essential ... -
Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.
(2020)Background: An increasing number of anti‐cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence ... -
Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor
(2020)The inhibition of tumor necrosis factor (TNF) through the use of either antibodies or soluble receptors is a highly effective strategy for the clinical control of chronic inflammatory conditions such as rheumatoid arthritis. ... -
Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids
(InTech, 2018)The poor clinical translation of oncological nanomedicine products is one of the greatest challenges faced by research today. The use of reductionist in vitro models of human cancer and non-predictive animal models is ...
