Clinical Medicine: Recent submissions
Now showing items 361-380 of 1003
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Editorial: Tregs and BCG - Dangerous liaisons in TB
(2010)A discussion on paper by Ho et al. providing evidence to support the hypothesis that Treg cells induced by environmental mycobacteria do indeed constrain immunity induced by BCG. -
Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis.
(2012)Background: Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number of mechanisms ... -
The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study.
(2013)A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species distribution, global partners in the NTM-Network ... -
Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey
(2008)Tuberculosis control depends on successful case finding and treatment of individuals infected with Mycobacterium tuberculosis. Passive case finding is widely practised: the present study aims to ascertain the consensus and ... -
Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease
(BMC, 2007)Background: Bovine tuberculosis is an enduring disease of cattle that has significant repercussions for human health. The advent of high-throughput functional genomics technologies has facilitated large-scale analyses of ... -
T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis
(Elsevier, 2007)Autophagy is a recently recognized immune effect or mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ... -
Characterisation of circulating tumour cells in men with advanced prostate cancer and correlation with numbers of circulating and tissue-based inflammatory cells
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Many men with prostate cancer present with advanced stage disease, and in these men treatment is directed towards improved survival and quality-of-life rather than cure. Exercise therapies are recognised to have benefits ... -
Respiratory measures in amyotrophic lateral sclerosis
(2018)Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that causes skeletal muscle weakness, including muscles involved with respiration. Death often results from respiratory failure within ... -
Left atrial invasion by pulmonary adenocarcinoma
(2007)A 72-year-old female presented with haemoptysis. CT thorax demonstrated a right lower lobe mass infiltrating the left atrium (Fig. 1 ). Bronchoscopy and biopsy confirmed endobronchial adenocarcinoma. Left atrial invasion ... -
Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis
(2015)Female reproductive tract tuberculosis is rarein the developed world and its diagnosis ischallenging. However, this case illustrates theimportance of including female reproductivetract tuberculosis in the differential for ... -
TB osteomyelitis
(Oxford University Press, 2016)Osteoarticular TB is very rare and as such, physicians are less experienced in diagnosing osteoarticular TB. This is compounded by the fact that the diagnosis of osteoarticular TB is difficult to achieve. Therefore, awareness ... -
Extensively drug-resistant tuberculosis: first report of a case in Ireland
(2008)Extensively drug-resistant tuberculosis (XDR-TB) is an emerging global threat. Between 2002 and 2007 sixteen countries in the European Union (EU) reported at least one case of XDR-TB [1]. Infection is characterised by ... -
Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
(Oxford University Press, 2016)Background: Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). ... -
Response: Disseminated tuberculosis.
(Oxford University Press, 2017)Lymphopaenia is described among patients with tuberculosis.The lymphocyte count for the patient in our publication prior to treatment was 0.8 (1–2 1016ml). At the time of writing, he is still receiving his anti-tuberculous ... -
Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages
(2000)Human alveolar macrophages (AMφ) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive ... -
Mismatch Negativity as an Indicator of Cognitive Sub-Domain Dysfunction in Amyotrophic Lateral Sclerosis
(2017)Objective: To evaluate the utility of mismatch negativity (MMN), a neurophysiologic marker of non-motor cognitive processing, in amyotrophic lateral sclerosis (ALS). Methods: 89 patients, stratified into 4 different ... -
Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice
(2002)A single intratracheal dose of porcine pancreatic elastase, which is cleared from the lung by 24 hours, was administered to wild-type, IL-1β type 1 receptor-deficient, double TNF-α (type 1 and type 2) receptor-deficient, ... -
Genetic screening in sporadic ALS and FTD
(2017)The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least 10% of those diagnosed ... -
July 2017 ENCALS statement on edaravone
(2017)Neurologists of the ENCALS centers throughout Europe have discussed the potential of edaravone as anew therapy for amyotrophic lateral sclerosis (ALS,Motor Neuron Disease, MND) at the ENCALS meeting, 18–20 May 2017, in ... -
Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis
(2018)Objectives: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and ...
