Clinical Medicine: Recent submissions
Now showing items 341-360 of 1003
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?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)Background: Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of ... -
?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'.
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced ... -
Alternative therapeutics for oesophageal cancer : novel toxic bile acid derivatives to induce apoptosis and siRNA library screen to identify genes that regulate cell shape
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Oesophageal adenocarcinoma (OAC) is the sixth leading cause of cancer-related deaths worldwide, and has proven most challenging for surgeons as less than a third of patients are suitable for surgical resection due to ... -
Von Willebrand Factor, osteoprotegerin and protein C pathway in the pathogenesis of experimental cerebal malaria
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Plasmodium falciparum malaria infection is associated with an early marked increase in plasma VWF levels, together with a pathological accumulation of hyperreactive ultra-large VWF (ULVWF) multimers. Given the established ... -
The inflammatory degenerative continuum of HIV related cognitive impairment
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)This thesis is the result of three years of research from January 2011 to December 2013 examining the role of cognition in HIV infection in an Irish specialist HIV service. This had not previously been examined in Ireland. ... -
Development of a nanowire-based assay for cancer biomarker detection in complex biological fluids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)The cost of delivering healthcare continues to increase to phenomenal proportions with lung cancer, breast cancer, colorectal cancer and prostate cancer accounting for the majority of the economic burden associated with ... -
The role of novel IL-1 family members in Inflammatory Bowel Disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammatory Bowel Disease (IBD) is characterized by an imbalance between effector and regulatory arms of intestinal immunity. Emerging evidence suggests that IL-1 family members play a critical role in the maintenance of ... -
Exposure to reduced oxygenation following radiation exposure enhances the survival of prostate cancer cells in vitro: implications for radiation therapy delivery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Introduction: Hypoxia is a common feature of prostate tumours; hypoxic cells are more radioresistance compared to oxygenated cells. Hypoxic radioresistance has also been shown to be related to the duration of hypoxia prior ... -
Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to development of oesophageal adenocarcinoma (OAC), through a premalignant lesion, Barrett's oesophagus (BO). OAC has a 5-year survival of patients ... -
Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials
(2018)Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by nebulization or using pressurized metered dose inhalers, and in solid form by means of dry powder inhalers. However, NP ... -
Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs
(2018)Evidence supports the advantages of inhalation over other drug-administration routes in the treatment of lung diseases, including cancer. Although data obtained from animal models and conventional in vitro cultures are ... -
Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents
(2018)Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not a clear and complete protocol to define and relate the properties of ... -
Detection of long repeat expansions from PCR-free whole-genome sequence data
(2017)Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) andfragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution ... -
First-line nivolumab plus ipilimumab in advanced non-small-cell lung cancer (CheckMate 568): Outcomes by programmed death ligand 1 and tumor mutational burden as biomarkers
(2019)PURPOSE: CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment of advanced/metastatic non–small-cell lung cancer (NSCLC). We ... -
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
(2018)Group-2 innate lymphoid cells (ILC2) play critical roles in the initiation and maintenance of type-2 immune responses, predominantly through their production of the type-2 cytokines IL-5, IL-9, and IL-13. ILC2 are essential ... -
Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
(2018)Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle involving infections of an aquatic snail ... -
Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project
(2018)Introduction: The reported prevalence of ALK receptor tyrosine kinase gene (ALK) rearrangement in NSCLC ranges from 2% to 7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, ... -
Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.
(2019)The European Society of Gastrointestinal Endoscopy (ESGE) together with the United European Gastroenterology (UEG) recently developed a short list of performance measures for small-bowel endoscopy (i.e. small-bowel capsule ... -
Mental Capacity for Medical Treatment Decisions in Medical and Surgical Hospital Inpatients in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Mental capacity both merits and requires substantial consideration and attention in present-day clinical practice, research and legislation. This is the first research study in the Republic of Ireland to evaluate the ... -
A pulmonary mass with invasion into the heart
(2008)We describe the case of a 58 year old woman who presented with bronchial atypical carcinoid found at surgery to invade the left atrium along the pulmonary veins. A right pneumonectomy and removal of a portion of the ...
