Clinical Medicine: Recent submissions
Now showing items 401-420 of 1003
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Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis.
(2019)Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including ... -
Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease
(2019)Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are ... -
Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis
(2019)Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective neuroprotective therapy. Known genetic variants impair pathways, including RNA processing, axonal transport, and protein homeostasis. ... -
Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council
(Wiley, 2019)The Irish Brain Council is an independent group of organisations which have come together to influence and impact upon brain research in Ireland. The purpose of the Irish Brain Council is to promote ... -
Neurophysiological markers of network dysfunction in neurodegenerative diseases
(Elsevier, 2019)There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, ... -
Sequencing of therapy following first-line afatinib in patients with EGFR mutation-positive non-small cell lung cancer
(Elsevier, 2019)Objectives: With the availability of several epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), sequential therapy could potentially render EGFR mutation-positive non-small cell lung cancer a chronic ... -
Nivolumab plus ipilimumab in non-small-cell lung cancer
(2019)Nivolumab and ipilimumab, two therapeutic immune checkpoint inhibitor antibodies that block PD-1and CTLA-4, respectively, have indications in cancer as single agents and in combination. In this Review, we examine the ... -
Advancing the therapeutic potential of the IL-1 family in inflammatory diseases - Meeting report
(2019)On October 9th 2018 the Trinity College Dublin hosted a workshop forum at the Royal Irish Academy to discuss recent discoveries and current areas of focus in the field of IL‐1 family biology. The aim of this meeting was ... -
Current perspectives on the interleukin-1 family as targets for inflammatory disease.
(2019)Since the first description of interleukin-1 (IL-1) and the genesis of the field of cytokine biology, the understanding of how IL-1 and related cytokines play central orchestrat- ing roles in the inflammatory response has ... -
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
(2016)Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping, fatal neuro-degenerative disorders in which the molecular and pathogenic basis remains poorly understood. Ubiquitinated ... -
Evaluation of diagnostic and treatment strategies for the management of Helicobacter pylori infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Helicobacter pylori infection is responsible for chronic gastritis and the development of gastrointestinal disorders such as gastric or duodenal ulcers, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) ... -
The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis
(2012)The identification of regulatory T (Treg) cells was originally based on CD25 expression; however, CD25 is also expressed by activated effector T cells. FoxP3 is a more definitive marker of Treg cells, and CD4 +FoxP3 +CD25 ... -
Motor and extra-motor involvement in amyotrophic lateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Amyotrophic Lateral Sclerosis (ALS) is primarily associated with pathology in the motor cortex and corticospinal tract. Based on clinical observations, it is increasingly recognised that extra-motor symptoms add to the ... -
Vitamin D deficiency: cognition, mortality and resource utilisation - prospective associations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Introduction: The association between Vitamin D and bone health has long been known. In recent times there has been increasing research into the effects of Vitamin D beyond this well-established link. Although there has ... -
Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ... -
Synthesis and characterisation of aerosolised MIF inhitibitors for the treatment of respiratory disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)The main focus of this PhD thesis was to investigate the synthesis and characterisation of an aerosolised poly lactic-co-glycolic acid (PLGA) nanodrug delivery system for MIF enzyme inhibitors to modulate the physiological ... -
Polyunsaturated fatty acids, macrophages, and mediators of atherosclerosis: an in vitro investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Many cells are involved in the atherosclerotic process, but macrophages are present inevery phase of atherosclerosis and are heavily implicated as prime culprits in the molecular events that initiate, promote and complicate ... -
Nutritional and metabolic aspects of n-3 polyunsaturated fatty acids in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)The health benefits of fish oils, rich in the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are multi-faceted, spanning a number of human systems, including the cardiovascular, ... -
Folic acid fortification of flour : determination of the level that gives rise to unmetabolised folic acid in serum
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)To prevent neural tube defects the Food and Drug Administration (FDA) implemented mandatory folic acid fortification o f all flour milled in the USA at a level 140μg/100g. The Centers for Disease Control (CDC) have proposed ... -
The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both ...
