Clinical Medicine: Recent submissions
Now showing items 421-440 of 1003
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Postprandial lipoprotein metabolism in diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Cardiovascular disease is up to four times greater in patients with Type 2 diabetes compared with nonnoglycaemic individuals (Pyorala et al., 1987; Laakso and Lehto 1997). Abnormalities in lipid metabolism may, in part, ... -
The effects of conjugated linoleic acid on the human immune system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)The cells of the immune system are sensitive to their exogenous environment. Indeed the amount and type of nutrients, including fatty acids, which this environment contains all influence subsequent immune cell functioning. ... -
Dietary and genetic factors affecting the cholesteryl ester transfer protein and lipoprotein metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The cholesteryl ester transfer protein (CETP) plays an inherent role in the redistribution of neutral lipids between high density lipoproteins (HDL) and very low density lipoproteins (VLDL) and low density lipoproteins ... -
Tools and techniques for improving the assessment of exposure to food chemicals
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Exposure assessments are an integral part of risk assessment and are essential for protecting consumer health and factilitating international trade. The aim of this thesis was to explore the potential usefulness of a number ... -
Characterization of proteins associated with the LFA-1 mediated cytoskeletal / signaling complex in locomotory T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)LFA-1 plays a crucial role in all aspects of T cell locomotion in both immune physiological functions and pathological conditions. T cell locomotion is associated with translocation of protein kinase C isoenzymes β and δ ... -
The study of periodicity of eating & public health nutrition issues
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)This thesis set out to provide an objective understanding of periodicity of eating in a group of free- living adults, by determining the temporal pattern of nutrient intake during eating occasions throughout the day. A ... -
Development of a novel CD52 functionalised nanoparticle for the targeting of Chronic Lymphocytic Leukaemia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Nanomedicine has been recognised as a next-generation technology for the treatment and management of many disease states, including blood cancers. The term nanotechnology was first coined in 1974 and, is at the interface ... -
Data linkage in medical science using the resource description framework: the AVERT model
(2018)There is an ongoing challenge as to how best manage and understand ‘big data’ in precision medicine settings. This paper describes the potential for a Linked Data approach, using a Resource Description Framework (RDF) ... -
Dementia in the Acute General Hospital - Prevalence, Practices and Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Background The number of people living with dementia in Ireland is projected to increase exponentially in the coming decades. The international literature suggests, however, that the recognition of dementia is poor, ... -
Evaluation of Triple helix-forming Oligonucleotides as modulators of transcriptional initiation in erbB-2/HER-2-positive breast cancer : an anti-tumour approach
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Research over the last several decades has made tremendous strides in the identification of the components of the human genome. Genetic information is expressed by translation of DNA into functional proteins through the ... -
The Tumour Necrosis Factor region in coeliac disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Coeliac disease is a disease of the small intestine, characterised by villous atrophy and crypt hyperplasia. The disease can be defined as an intolerance in genetically susceptible individuals to certain storage proteins ... -
Methodological issues in risk assessment of human exposure to artificial sweeteners in food
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The primary aim of this thesis is in estimating food chemical intakes with a specific interest in the area of intense sweeteners. To date all studies of intense sweeteners have been extremely detailed both in the estimate ... -
Nutritional aspects of trans unsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ... -
Molecular aspects of human lipid metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The postprandial lipaemic response refers to the changes in lipid and lipoprotein concentrations after consumption of a meal containing more than 15g of long-chain fatty acids. The magnitude and duration of the response ... -
Tumourigenesis and resistance to Interferon alpha-treatment in Cutaneous T-cell Lymphoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Mycosis fungoides (MF) is a Cutaneous T-Cell lymphoma (CTCL) of unknown aetiology, and the mechanisms of tumourigenesis of this lymphoma are unclear. The diagnosis of MF is extremely challenging due to the fact that, in ... -
The role of folate in the development of colorectal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Colorectal cancer is a leading cause of morbidity and mortality in Europe and the USA each year. Most large bowel cancers arise within pre-existing adenomatous polyps or adenomas. Several case-control and prospective studies ... -
The pathophysiology of insulin resistance and modulation by aerobic exercise in obese and Type 2 diabetes subjects
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Insulin resistance is a major contributing factor to the development of Type 2 diabetes and cardiovascular disease. It has been difficult to characterise the aetiological progression because of the complex metabolic milieu ... -
Development of an antisense strategy to down-regulate gene expression in chronic myelogenous leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Since the discovery of mRNA down-regulation by sequences of complementary nucleic acids in 1977, there has been a drive to apply the antisense phenomenon to therapeutic settings. In theory the potential of antisense ... -
Surface layer proteins of Clostridium difficile as novel vaccine candidates
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Clostridium difficile is a major cause of antibiotic associated diarrhoea and pseudomembranous colitis in hospitalised patients. The major precipitating factor for C. difficile-associated disease (CDAD) is disruption of ... -
An extensive evaluation of the validity of reported energy intakes in the North/South Ireland food consumption survey
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)The North/South Ireland Food Consumption Survey (NSIFCS) was conducted between 1997 and 1999, on a representative sample of 1379 adults from the Republic of Ireland and Northern Ireland, aged 18 to 64 years. Food intakes ...
