Clinical Medicine: Recent submissions
Now showing items 441-460 of 1003
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The role of the bile acid deoxycholate in gastrointestinal epithelial cell signalling
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Environmental and dietary factors are implicated in the aetiology of human cancer. Bile acids, the amphiphilic derivatives of cholesterol, are strongly implicated in colonic and oesophageal carcinogenesis. While bile acids ... -
Novel molecular targets in advanced prostate cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Prostate Cancer (PCa) is the most commonly diagnosed cancer in men and a leading cause of morbidity and mortality among men in the United States and Western Europe. The aim of initial treatment in advanced PCa is to reduce ... -
An exploration of the referral patterns of a community palliative care team to specialist palliative care outpatient physiotherapy for community based individuals with advanced cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Introduction: Physiotherapy is a core discipline within specialist palliative care (SPC) services and has been shown to contribute to the management of common symptoms associated with advanced cancer such as fatigue, ... -
Characterisation of the redox protein Thioredoxin from the gastric pathogen Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Gastric colonisation by the Gram-negative bacterium Helicobacter pylori is the primary cause of peptic ulceration, type B chronic gastritis, gastric adenocarcinoma, and is linked to the progression of gastric MALT lymphoma. ... -
Chracterisation of the Epithelial barrier in early life and in atopic dermatitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Atopic dermatitis (AD) is the most common inflammatory disease of childhood. It is characterised clinically by chronic skin inflammation and pruritus. Atopic dermatitis is associated with several co-morbidities, including ... -
Antimicrobial susceptibility, resistance determinants and molecular epidemiology of Neisseria gonorrhoeae in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health ... -
Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ... -
The nerve of facial expression, impact of its anatomical variations on iatrogenic surgical injury and a novel MRI diffusion weighted imaging technique to image its intra-parotid course
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)This doctorate in clinical medicine set out to assess how variations in facial nerve anatomy to the intra-parotid venous system could impact on surgical access to the parotid gland or the mandible, and explored methods to ... -
Examining links between Factor Xa, endothelial dysfunction, adverse pregnancy outcomes and cardiovascular disease in Lupus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Systemic lupus erythematosus (SLE) is a multisystemic autoimmune rheumatic disease (ARD) associated with significant morbidity and mortality, which presents mainly in women of childbearing age. Women with SLE have a 5-10-fold ... -
Transcriptional response to prolonged acid exposure and genetic divergence in Helicobacter pylor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Helicobacter pylori infection is strongly associated with gastritis, peptic ulcer and gastric adenocarcinoma. Molecular mechanisms involved in H. pylori adaptation and clinical consequences of infection are unclear. This ... -
The nutritional status of hospital patients and healthy elderly living in the community
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Protein-energy undernutrition is known to occur in patients on admission to hospital. In a prospective study of 594 sequential hospital admissions, we assessed the prevalence of undernutrition among patients on admission ... -
Assessment of platelet activation and function in the early and late phases following acute TIA and ischaemic stroke
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Aims: The purpose of this thesis was to comprehensively assess the impact of commencing commonly prescribed antiplatelet regimens on platelet activation, platelet function and platelet turnover after TIA or ischaemic stroke, ... -
Investigation of interactions of nanoparticles with components of the human vascular microenvironment : platelets, plasma and endothelial cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Nanotechnology is defined as ‘the understanding and control of matter at dimensions less than 100 nanometers’, and exploits the novel physical, chemical and biological properties of materials. Nanomedicine, application of ... -
Investigation of the role of RACKI in T lymphocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Induction of the innmune response and production of pro-inflammatory cytokines results in the upregulation of ICAM-1 expressed on endothelial cells. Binding of ICAM-1 to the β2 integrin receptor LFA-1 on T cells induces T ... -
Microcrack distributions in bone : effects of stress and bone mineral density
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The work is divided into four main sections. Chapter 2 it was performed compression and bending tests, with the use of a dye sequence technique. The tests were carried out to detect and measure microdamage development after ... -
The role of inflammation and macrophage accumulation in the development of obesity induced Type 2 diabetes mellitus and the possible therapeutic effects of long chain n-3 polyunsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Obesity gives rise to a state of chronic, low-grade inflammation characterised by inflamed white adipose tissue (WAT) with increased infiltration of macrophages termed adipose tissue macrophages (ATM). These ATM produce ... -
Investigation of ABO blood group expresser phenotype
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project were to study the variability of the ABO blood group expression on human platelets and to explore the underlying molecular mechanisms. 541 Irish blood donors were studied. The recently described ... -
Genetic and environmental risk factors in age-related macular degeneration in vitro, in vivo and population studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project are to show the potential sites of interaction between underlying genetic susceptibilities and environmental influences (cigarette smoke) in neovascular AMD. Our current hypothesis proposes that ... -
Clinical, metabolic and biochemical responses to a diet and aerobic excercise intervention in early-onset type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)This study was a longitudinal, randomised, controlled trial. Two primary groups of subjects were recruited for comparison: young obese patients (less than 30 years of age) with early- onset type 2 diabetes (YT2), and a ... -
Syphilis and HIV co-infection in Dublin; strategies to enhance diagnosis, investigation and management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Following historically low levels of reported cases of syphilis in Dublin in the 1990s there was a large outbreak of syphilis reported in 2001. Numerous interventions were implemented and the rates again decreased in 2003. ...
