Clinical Medicine: Recent submissions
Now showing items 521-540 of 1003
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Therapeutic outcomes, immunological responses to treatment and vaccine preventative strategies for Hepatitis C in HIV seropositive individuals
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Introduction: HIV and Hepatitis C virus (HCV) represent significant causes of morbidity and mortality worldwide. Because of shared routes of transmission co-infection is common. Recent advances in treatment for both ... -
Examining the breadth and burden of chronic kidney disease in community-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Introduction: Chronic kidney disease (CKD), characterised by reductions in glomerular filtration rate (GFR), is associated with premature mortality and end stage kidney disease. Older adults have the highest prevalence of ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ... -
Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ... -
Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition characterised by relentless upper and lower motor neuron degeneration. The clinical spectrum, symptoms onset, genetic vulnerability and ... -
Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ... -
Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
RSOS submission raw data
(RSOS, 2017) -
The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
(Springer Paris, 2017)Background Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ... -
An investigation of epigenetic effects in Atherosclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Epigenetic mechanisms may explain some of the missing heritability associated with CVD and how external factors such as diet, environment and lifestyle contribute to disease development and progression. This thesis aimed ...
