Clinical Medicine: Recent submissions
Now showing items 541-560 of 1003
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Effects of bile acids and fatty acids on cell signalling in human colorectal cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Colorectal cancer is a multifactorial disease. The interplay between genetic and environmental factors leads to the development of CRC. There have been great advancements in the knowledge of genetic alterations leading to ... -
Novel mediators regulating innate and adaptive type 17 immune responses
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The discovery of a third subset of T helper cells and more recently innate T cell subsets which preferentially express IL-17A has led to intensive investigation into the roles these cells play in both host defence and ... -
Aspects of muscle performance, mobility limitations, excercise interventions and cognitive functioning in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)In section A, two studies were conducted to systematically investigate and compare the cross sectional and longitudinal physiological determinants of the age-related loss of lower extremity muscle power in healthy and ... -
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ... -
Protein Kinase Cη : regulation of expression and functional role in human T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Protein kinase Cη (PKCη) is a member of the novel PKC subfamily of serine/threonine kinases that has been shown to play critical roles in cell differentiation, proliferation, secretion and apoptosis in several cell types. ... -
The role of Ma1 in macrophage responses to tuberculosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Heterozygotes for the common S180L polymorphism in the TLR adaptor Mal (TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas homozygotes are at increased risk. We report that Mal ... -
Biophysical and immunological pathway endophenotyping of atopic dermatitis stratified for filaggrin mutations
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Atopic dermatitis (AD, eczema) is a common inflammatory skin disease, driven and modified by environmental, immunological and genetic factors. It is characterized clinically by inflammatory and pruritic skin lesions and ... -
Investigating the role of constitutively active truncated androgen receptor splice variants in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine, 2012)The androgen receptor (AR) is fundamental for the growth and survival of normal and malignant prostate cells. Therefore, androgen deprivation therapy remains the first‐line treatment for disseminated disease, however, ... -
The association between Fusobacterium nucleatum Outer Membrane Vesicles and Colonic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Fusobacterium nucleatum, a gram-negative spindle-shaped anaerobic bacterium, is a component of the human microbiome that primarily inhabits the oral cavity and is associated with many diseases, including sinusitis, ... -
Vitamin D in older adults and its relationship to cognition, blood pressure, mood and falls
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)An increasing body of evidence supports a role for vitamin D in cognition, blood pressure, mood and falls. Vitamin D deficiency is prevalent in older adults and might provide an alternative novel treatment strategy for ... -
Enternal nutrition in the community setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The practice of tube feeding patients outside the acute hospital setting has existed in Ireland for over a decade. Anecdotal evidence (mainly from hospital dietitians) suggested that the care services for these patients ... -
Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
(2017)Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has ... -
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
(2016)Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and ... -
A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution
(2016)Single-stranded DNA binding proteins (SSBs) play an important role in DNA processing events such as replication, recombination and re- pair. Human single-stranded DNA binding pro- tein ... -
Nucleophosmin: From structure and function to disease development
(2016)Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement ... -
HSSB1 (NABP2/OBFC2B) is regulated by oxidative stress
(2016)The maintenance of genome stability is an essential cellular process to prevent the development of diseases including cancer. hSSB1 (NABP2/ OBFC2A) is a critical component of the DNA damage response where it participates ... -
Short term ex-vivo expansion of circulating head and neck tumour cells
(2016)Minimally invasive techniques are required for the identification of head and neck cancer (HNC) patients who are at an increased risk of metastasis, or are not responding to therapy. An approach utilised in other solid ... -
In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC
(2016)Clinical PI3K inhibition has been somewhat disappointing, due to both inadequate patient stratification and compensatory cell signalling through bypass mechanisms. As such, investigation of PI3K-MEK co-targeted inhibition ... -
SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
(2016)Expression of the SASH1 protein is reduced in a range of human cancers and has been implicated in apoptotic cancer cell death. This study investigated whether increasing SASH1 expression could be a useful therapeutic ... -
Laser speckle correlation as a non-contact ocular microtremor measurement technique
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Ocular microtremor (OMT) is high frequency, low amplitude fixational eye movement present in all healthy people. It occurs even while the eye appears to be at rest. Benefits of measuring OMT have been proven in a number ...
