Clinical Medicine: Recent submissions
Now showing items 661-680 of 1003
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Migration of lymphoma and lymphocyte T cells on flat and grooved microfabricated surfaces : comparative analysis of peripheral blood T lymphocytes and lymphoma human T cell line HUT78
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Normal and malignant cell migration represents a fundamentally important process involved in tissue growth and development, inflammation and cancer metastasis. Leukocyte trafficking from blood into tissues is currently ... -
Non-invasive molecular tests for H. pylori
(Cogoro, 2016) -
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland
(2017)The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304* (or p.R304*; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health ... -
Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.
(2014)Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific ... -
Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation.
(2012)Risk alleles for complex diseases are widely spread throughout human populations. However, little is known about the geographic distribution and frequencies of risk alleles, which may contribute to differences in disease ... -
Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae.
(2008)Evolution of the bear family Ursidae is well investigated in terms of morphological, paleontological, and genetic features. However, several phylogenetic ambiguities occur within the subfamily Ursinae (the family Ursidae ... -
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
(2016)The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to ... -
Ancestral polymorphisms and sex-biased migration shaped the demographic history of brown bears and polar bears.
(2013)Recent studies have reported discordant gene trees in the evolution of brown bears and polar bears. Genealogical histories are different among independent nuclear loci and between biparentally inherited autosomal DNA (aDNA) ... -
Replication of a distinct psoriatic arthritis risk variant at the IL23R locus
(2016)Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with the presence of psoriasis. Although the majority of PsA genetic risk loci identified also confer risk for psoriasis, the difference in ... -
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus
(2015)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for ... -
r2VIM: A new variable selection method for random forests in genome-wide association studies
(2016)Background Machine learning methods and in particular random forests (RFs) are a promising alternative to standard single SNP analyses in genome-wide association studies (GWAS). RFs provide variable importance measures ... -
Patient journey to a specialist amyotrophic lateral sclerosis multidisciplinary clinic: an exploratory study.
(2015)BACKGROUND: The multidisciplinary approach in the management of Amyotrophic Lateral Sclerosis (ALS) has been shown to provide superior care to devolved care, with better survival, improved quality of care, and quality ... -
Analysis of pro [-2] PSA: A novel biomarker that significantly improves the detection of prostate cancer
(2015)Aim: In order to effectively select patients for prostate biopsy more accurate biomarkers of disease are needed. The objective of this study was to analyse the clinical utility of a novel biomarker; pro [-2] PSA in order ...
