Clinical Medicine: Recent submissions
Now showing items 641-660 of 1003
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Minimal residual disease in cancer of the oesophagus and gastro-oesophageal junction
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Epithelial tumours are the most common form of cancer and are responsible for the majority of cancer-related deaths in Western industrialized countries. Minimal residual disease following neo-adjuvant therapy or primary ... -
A study of postprandial lipoprotein metabolism and glycaemic control in a population with type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ... -
A novel inflammatory mediator in sinus disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ... -
Differential gene expression in diabetes : effects on postprandial lipoproteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Diabetes is responsible for a large increase in cardiovascular risk which in many studies has not been reduced by improvement in blood sugar. The postprandial period in diabetes is associated with considerable disturbance ... -
The immune response to Hepatitis C host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Immune response to Hepatitis C; Host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source. A coordinated response from both the innate and adaptive arms of ... -
Development of a tissue-specific prodrug activation approach to prostate cancer gene therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Prostate cancer is the most common fatal cancer in Irish men after lung and colorectal cancer. Since the risk of prostate cancer rises with age, its impact is likely to increase as the population ages. Standard treatments ... -
Investigation of gene amplification and expression in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The purpose of this thesis was to identify significant genetic amplifications and protein expression of a gene or genes that have not been recognised as overamplified to date in prostate cancer. Methods used: -- 1) ... -
P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
Studies on the interaction of Helicobacter pylori with extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Helicobacter pylori is a common human pathogen that persistently colonises the stomach of half the worlds population. The majority of people infected with H. pylori are asymptomatic, however, a proportion develop severe ... -
An investigation of T lymphocyte migration induced by CD44 activation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)This thesis investigates the role of CD44 in signalling active migration in T lymphocytes. A number of murine studies have demonstrated that loss of CD44 expression by T lymphocytes resulted in a delayed migration to sites ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
The transcriptomic analysis of low pH and bile acid induced gene expression in oesophageal cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Oesophageal adenocarcinoma (OAC) commonly arises from the presence of a premalignant lesion known as Barrett’s Oesophagus (BO). Gastro-oesophageal reflux disease (GORD) has been identified in epidemiological studies as a ... -
Estimation of exposure to food packaging migrants in a sample of Irish children
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Food packaging materials are not inert and transfer chemicals, known as migrants, into food. As the presence of chemicals in foods is a highly regulated area, food packaging migrants must undergo a risk assessment procedure ... -
Inherited variation in the xenobiotic response system in inflammatory bowel disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The aim of this study was to further the understanding regarding the genetic background of Inflammatory Bowel Disease (IBD). IBD patients can be classified into two major phenotypes, Crohn’s disease (CD) and ulcerative ... -
A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
Post operative atrial fibrillation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ... -
A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ... -
Genetic association study of coeliac disease in the Irish population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The aim of the present study was to investigate the genetic contribution of genes or regions other than the HLA to coeliac disease (CD) susceptibility in the Irish population. Genes selected for analysis in this study were ... -
Inflammation and oesophageal cancer : a study of genetic polymorphisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Cancer is a major medical challenge of this era. About one in every three persons develops cancer in his lifetime. By the time they are diagnosed, most cancers have already metastasized. The treatment of cancer depends ... -
New biochips for a three-dimensional study of transendothelial leukocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)An important step in the inflammatory response is the recruitment of leukocytes into tissues through the endothelial cells which line blood vessels. Transendothelial migration (TEM) is the result of a multistep cascade in ...
