Clinical Medicine: Recent submissions
Now showing items 861-880 of 1003
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Postal questionnaire survey: the use of sleeping with the head of the bed tilted upright for treatment of orthostatic hypotension in clinical practice.
(2006)Orthostatic hypotension (OH) is common and affects one in five community-living older persons [1]. The incidence is higher amongst older in-patients [2] and those attending a syncope clinic [3]. The treatment of OH is ... -
Correlates of frailty in Alzheimer's disease and mild cognitive impairment.
(2011)The global prevalence of dementia is rising with Alzheimer's disease (AD) accounting for 50–60% of all cases and mild cognitive impairment (MCI) its precursor [1, 2]. Although the clinical hallmark of AD is progressive ... -
Diabetes mellitus and apoptosis:inflammatory cells
(2009)Since the early observation that similarities between thyroiditis and insulitis existed, the important role played by inflammation in the development of diabetes has been appreciated. More recently, experiments have shown ... -
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis.
(2014)Background Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier ... -
Insulin receptor substrate 2 and FozO3a signaling are involved in E-Cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells
(2011)Insulin receptor substrate (IRS) proteins comprise a family of adaptor molecules that integrate extracellular signals from insulin and other ligands to intracellular effectors such as phosphoinositide 3-kinase and mitogen ... -
Identification of transcriptional targets associated with the expression of p210 Bcr-Abl
(2006)Objectives: Chronic myeloid leukaemia is caused by the expression of the p210 Bcr-Abl fusion protein which results from the Philadelphia translocation, t(9;22). This oncogene has been the focus of extensive research. ... -
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.
(2014)The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic ... -
Functions and therapeutic roles of exosomes in cancer.
(2014)The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, ... -
2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up.
(2014)To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO Consensus Conference on Lung Cancer was held on ... -
The establishment of an ISO compliant cancer biobank for Jordan and its neighboring countries through knowledge transfer and training.
(2014)Research studies aimed at advancing cancer prevention, diagnosis, and treatment depend on a number of key resources, including a ready supply of high-quality annotated biospecimens from diverse ethnic populations that can ... -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
(2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ... -
Genome stability pathways in head and neck cancers.
(2013)Genomic instability underlies the transformation of host cells toward malignancy, promotes development of invasion and metastasis and shapes the response of established cancer to treatment. In this review, we discuss recent ... -
IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.
(2013)The Interleukin-23 (IL-23)/IL-23R signaling axis is an important inflammatory pathway, involved in the stimulation and regulation of the T helper (Th) 17 lymphocytes, resulting in the production of IL-17. Aside from ... -
Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
(2013)Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified ... -
RanGTPase: A Candidate for Myc-Mediated Cancer Progression
(2013)BACKGROUND: Ras-related nuclear protein (Ran) is required for cancer cell survival in vitro and human cancer progression, but the molecular mechanisms are largely unknown. METHODS: We investigated the effect of the ... -
Driving cessation in patients attending a memory clinic.
(2005)BACKGROUND: Driving is an increasingly important form of transport for older people. Dementia is common in later life and will eventually lead to driving cessation, which reduces the public health risk of impaired driving ... -
Correlation of accelerometry with clinical balance tests in older fallers and non-fallers
(2009)BACKGROUND: falls are a common cause of injury and decreased functional independence in the older adult. Diagnosis and treatment of fallers require tools that accurately assess physiological parameters associated with ... -
An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)
(2014)Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ... -
Is low iron status a risk factor for neural tube defects?
(2014)Background: Folic acid supplements can protect against neural tube defects (NTDs). Low folate and low vitamin B12 status may be maternal risk factors for having an NTD affected pregnancy. However, not all NTDs are preventable ...
