Clinical Medicine: Recent submissions
Now showing items 881-900 of 1003
-
Mitochondrial uncoupling protein 1 expression in thymocytes.
(2008)Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out ... -
Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy
(2008)The aim of this study was to demonstrate the constitutive expression of mitochondrial uncoupling protein 1 (UCP 1) in pure thymocytes using laser scanning confocal microscopic imagery. To that end we probed thymocytes from ... -
Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection.
(2008)Human macrophages infected with Mycobacterium tuberculosis may undergo apoptosis. Macrophage apoptosis contributes to the innate immune response against M. tuberculosis by containing and limiting the growth of mycobacteria ... -
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells.
(2011)BACKGROUND: Dendritic cells (DCs) connect innate and adaptive immunity, and are necessary for an efficient CD4+ and CD8+ T cell response after infection with Mycobacterium tuberculosis (Mtb). We previously described the ... -
A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection.
(2007)Macrophages can undergo apoptosis after infection with Mycobacterium tuberculosis. This macrophage response deprives the bacillus of its niche cell and supports the host response through better antigen presentation. The ... -
Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages
(2014)Clostridium difficile is the leading cause of hospital-acquired diarrhoea worldwide, and if the bacterium is not cleared effectively it can pose a risk of recurrent infections and complications such as colitis, sepsis and ... -
Lessons of ALS imaging: Pitfalls and future directions - A critical review
(2014)Background: While neuroimaging in ALS has gained unprecedented momentum in recent years, little progress has been made in the development of viable diagnostic, prognostic and monitoring markers. Objectives: To identify ... -
New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid.
(2014)We have prepared a new panel of 23 BA derivatives of DCA, chenodeoxycholic acid (CDCA) and lithocholic acid (LCA) in order to study the effect of dual substitution with 3-azido and 24- amidation, features individually ... -
Bcr-Abl regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation is required for proliferation and drug resistance
(2006)The BCR-ABL oncogene is the hallmark of chronic myeloid leukemia, a clonal hematopoietic stem cell disorder. BCR-ABL displays constitutive tyrosine kinase activity, required for its transformation ability. Although the ... -
Connective tissue growth factor antagonizes transforming growth factor-?1/Smad signalling in renal mesangial cells
(2012)The critical involvement of TGF-?1 (transforming growth factor-?1) in DN (diabetic nephropathy) is well established. However, the role of CTGF (connective tissue growth factor) in regulating the complex interplay of TGF-?1 ... -
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
(2010)Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2 immunity-responsible for protective immune responses to helminth ... -
Adenylate cyclase toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.
(2008)Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. We have previously ... -
Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1 and MEK
(2005)Chronic myeloid leukemia (CML) is caused by the constitutively active Bcr-Abl tyrosine kinase. This fusion protein is generated by the Philadelphia translocation t(9;22). CML is a progressive condition that invariably ... -
Molecular Medicine Ireland Guidelines for Standardized Biobanking
(Mary Ann Liebert, Inc, 2010) -
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis
(2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility to ... -
Myeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
(2011)Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like ...
