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Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

dc.contributor.authorPalsson Mcdermott, Evaen
dc.contributor.authorKeane, Josephen
dc.contributor.authorO'Neill, Lukeen
dc.contributor.authorSheedy, Fredericken
dc.contributor.authorJohnston, Danielen
dc.contributor.authorGleeson, Lauraen
dc.date.accessioned2015-02-17T16:59:41Z
dc.date.available2015-02-17T16:59:41Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationPalsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, 1, 2015, 65-80en
dc.identifier.issn1550-4131en
dc.identifier.otherYen
dc.descriptionPUBLISHEDen
dc.description.abstractTLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify PKM2 as a critical modulator of IL-1 b production and the Warburg effect in LPS-activated macrophages, highlighting it as a target in cancer and inflammationen
dc.description.sponsorshipWe thank Science Foundation Ireland, the European Research Council, the Health Research Board, European Community Seventh Framework Pro- gramme (FP7-2007-2013) under grant agreement No. HEALTH-14-2011- 281608 ‘TIMER’, Wellcome Trust, Baggot St Hospital Trust, and National Insti- tutes of Health for fundingen
dc.format.extent65-80en
dc.language.isoenen
dc.relation.ispartofseriesCell metabolismen
dc.relation.ispartofseries21en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectTLR4-activated macrophagesen
dc.subject.lcshTLR4-activated macrophagesen
dc.titlePyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/josephmken
dc.identifier.peoplefinderurlhttp://people.tcd.ie/djohnsten
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/palssoneen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fsheedyen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lgleesonen
dc.identifier.rssinternalid98578en
dc.identifier.doihttp://dx.doi.org/10.1016/j.cmet.2014.12.005en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDTagImmune systemen
dc.subject.TCDTagImmunology, Immunotherapyen
dc.subject.TCDTagMolecular Biologyen
dc.identifier.orcid_id0000-0001-5313-385Xen
dc.contributor.sponsorEuropean Union Framework Programme 7 (FP7)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.identifier.urihttp://hdl.handle.net/2262/73269


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