Predicting prognosis in amyotrophic lateral sclerosis: a simple algorithm

Abstract

The objective of the study was to develop and validate a practical prognostic index for patients with amyotrophic lateral scleroses (ALS) using information available at the first clinical consultation. We interrogated datasets generated from two population-based projects (based in the Republic of Ireland and Italy). The Irish pa- tient cohort was divided into Training and Test sub-co- horts. Kaplan–Meier methods and Cox proportional hazards regression were used to identify significant pre- dictors of prognoses in the Training set