Role of Notch signaling in regulating innate immunity and inflammation in health and disease
Citation:
Shang Y*, Smith S*, Hu X., Role of Notch signaling in regulating innate immunity and inflammation in health and disease, Protein & Cell, 7, 3, 2016, 159 - 174Download Item:
Abstract:
The Notch signaling pathway is conserved from
Droso-
phila
to mammals and is critically involved in develop-
mental processes. In the immune system, it has been
established that Notch signaling regulates multiple
steps of T and B cell development in both central and
peripheral lymphoid organs. Relative to the well docu-
mented role of Notch signaling in lymphocyte develop-
ment, less is known about its role in regulating myeloid
lineage development and function, especially in the
context of acute and chronic in
fl
ammation. In this review
article, we will describe the evidence accumulated dur-
ing the recent years to support a key regulatory role of
the Notch pathway in innate immune and in
fl
ammatory
responses and discuss the potential implications of
such regulation for pathogenesis and therapy of
in
fl
ammatory disorders.
Author's Homepage:
http://people.tcd.ie/smithsiDescription:
PUBLISHED*Joint first authors
Author: SMITH, SINEAD
Type of material:
Journal ArticleCollections
Series/Report no:
Protein & Cell7
3
Availability:
Full text availableSubject:
immunitySubject (TCD):
Cancer , Genes & Society , Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1007/s13238-016-0250-0Metadata
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