dc.contributor.advisor | Foster, Tim | |
dc.contributor.author | Mulcahy, Michelle | |
dc.date.accessioned | 2017-02-08T10:26:09Z | |
dc.date.available | 2017-02-08T10:26:09Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Michelle Mulcahy, 'The interaction of clumping factor B and iron-regulated surface determinant protein A of Staphylococcus aureus with the squamous epithelial cell envelope protein loricrin', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2013, pp 257 | |
dc.identifier.other | THESIS 10149 | |
dc.description.abstract | Staphylococcus aureus permanently colonises the anterior nares of 20% of the human population while the remainder is colonised intermittently. Clumping factor B (ClfB) is a surface-expressed staphylococcal protein that plays a role in nasal colonisation. ClfB promotes bacterial adherence to human desquamated epithelial cells (squames) and ClfB-deficient strains of S. aureus displayed a significantly reduced ability to colonise the nares of rodents and healthy human volunteers. The iron-regulated surface determinant protein A (IsdA) is also involved in nasal colonisation. IsdA promotes bacterial adherence to squames and an interaction between IsdA and loricrin has been suggested. ClfB binds to the aC-region of fibrinogen and to the tail region of the surface- exposed squamous cell protein cytokeratin 10 (K10). The ClfB-binding site within K10 was localised to the glycine serine-rich omega loops in the K10 tail. Unpublished evidence from E. Walsh and T.J. Foster suggested that ClfB binds to loricrin, another structural protein present in the cornified envelope. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Microbiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15355663 | |
dc.subject | Microbiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | The interaction of clumping factor B and iron-regulated surface determinant protein A of Staphylococcus aureus with the squamous epithelial cell envelope protein loricrin | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 257 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/79259 | |