| dc.contributor.author | O'BYRNE, KEN | en |
| dc.date.accessioned | 2017-05-24T14:10:00Z | |
| dc.date.available | 2017-05-24T14:10:00Z | |
| dc.date.issued | 2016 | en |
| dc.date.submitted | 2016 | en |
| dc.identifier.citation | Box J.K, Paquet N, Adams M.N, Boucher D, Bolderson E, O'Byrne K.J, Richard D.J, Nucleophosmin: From structure and function to disease development, BMC Molecular Biology, 17, 1, 2016, 19- | en |
| dc.identifier.other | Y | en |
| dc.description.abstract | Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including
mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for
normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and
sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-
oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in
the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers. | en |
| dc.description.sponsorship | This work was supported by a NHMRC project Grant (1066550), an ARC project Grant (D.J.R, DP 120103099) and by a Queensland Health Senior Clinical Research Fellowship (K.J.O.). M.A. holds a NHMRC Early Career Fellowship (1091589). E.B. is supported by an Advance Queensland Research Fellowship. | en |
| dc.format.extent | 19 | en |
| dc.relation.ispartofseries | BMC Molecular Biology | en |
| dc.relation.ispartofseries | 17 | en |
| dc.relation.ispartofseries | 1 | en |
| dc.rights | Y | en |
| dc.subject | Nucleophosmin 1 DNA repair Cancer Apoptosis | en |
| dc.subject.lcsh | Nucleophosmin 1 DNA repair Cancer Apoptosis | en |
| dc.title | Nucleophosmin: From structure and function to disease development | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/obyrneke | en |
| dc.identifier.rssinternalid | 156634 | en |
| dc.identifier.doi | http://dx.doi.org/10.1186/s12867-016-0073-9 | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.rssuri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983260759&doi=10.1186%2fs12867-016-0073-9&partnerID=40&md5=3b0bcc59a72a8fff0d488b4862cd5cc8 | en |
| dc.identifier.uri | http://hdl.handle.net/2262/80214 | |
