Genetics: Recent submissions
Now showing items 161-180 of 578
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Olfactory-avoidance habituation in Drosophila melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Habituation is a form of sensory filtering in response to prolonged or repeated stimuli in the environment [Harris, 1943; Thompson and Spencer, 1966; Christoffersen, 1997; Rankin et al., 2009], It provides biological ... -
Detection of selection in mammalian genomes and populations
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Genome-wide scans for evidence of positive selection in mammalian genomes have recently become possible with the availability of whole genome sequences. They offer a chance to identify those genes that were of most importance ... -
Investigating mechanisms underlying olfactory habituation in Drosophila melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Habituation is a common form of learning and memory that has been poorly studied despite its fundamental importance and clinical significance. During habituation, the behavioural response to a prolonged or repeated ... -
Optimisation of a suppression and replacement therapeutic strategy for animal models of rhodopsin-linked autosomal dominant Retinitis Pigmentosa
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The focus of research presented in this PhD thesis was optimising a therapeutic strategy for an inherited retinal disorder termed Retinitis Pigmentosa (RP). RP is a disease in which the photoreceptors progressively degenerate. ... -
Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The H-NS protein represses the transcription of hundreds of genes in Gram-negative bacteria. De-repression is achieved by a multitude of mechanisms, many of which involve binding of a protein to DNA at the repressed promoter ... -
Understanding the molecular interplay between bacterial pathogens and hosts : an evolutionary approach
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The emergence of ecological adaptations is a fundamental conundrum in evolutionary biology. A magnificent and astonishing diversity of life forms occupy a myriad of ecological niches, from stable intra-cellular nutrition-rich ... -
Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2015)Polycombs are evolutionary conserved epigenetic regulators crucial for specification of cell types during development. They assemble in multiprotein complexes to modify amino terminal tails of histone H3 at lysine 27 to ... -
An investigation of the specificity of interaction in two-component systems using YycFG and PhoPR of Bacillus subtilis as a model system
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Presented in this thesis is a study of the specificity of interaction between histidine kinases and response regulators in two-component systems using YycFG and PhoPR as model system in B. subtilis. -
Genomewide admixture mapping of African cattle
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Genome-wide SNP analyses of cattle populations have become practical. In parallel, advanced and sophisticated statistical packages make it practical to extract embedded genetic information; for example differential levels ... -
Staphylococcus lugdunensis : Genome sequence, genetic systems, virulence and an amplifiable isd locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus lugdunensis is a coagulase negative staphylococcus (CoNS). Infections caused by CoNS are normally less severe than infections caused by S. aureus. However, S. lugdunensis is associated with a series of severe ... -
Sustained expression of fis, the gene coding for the Fis nucleoid-associated protein, during the stationary phase of growth in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)The Factor for Inversion Stimulation (Fis) is a global regulator of virulence genes in Salmonella enterica serovar Typhimurium. Previously, the Fis protein was throught to be expressed only during the early exponential ... -
A study of the regulation of aminoacyl tRNA synthetase gene expression in Bacillus by T-box regulatory elements
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2010)The T-box antitermination mechanism is commonly used for the regulation of aminoacyl tRNA synthetase gene expression in Gram positive bacteria. However, expression of lysyl tRNA synthetases is rarely controlled in this ... -
Expression of hns and stpA in Salmonella enterica servoar Typhimurium
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)H-NS-like proteins are widespread amongst Enterobacteriaceae and other Gramnegative bacteria. They are small (15 kDa) nucleoid associated proteins involved in many cellular processes such as replication, transposition, ... -
Investigation of the role of the BcI-2 family proteins in Ras-induced transformation
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)RAS is a proto-oncogene that is found mutated in 25% of human tumours. Deregulated Ras expression is typically insufficient to transform cells as it triggers anti-proliferative responses that altogether limit tumorigenesis. ... -
Population and genomic variation of immune genes in chicken
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Achieving an understanding of the processes shaping diversity at chicken immune genes illuminates their population history, relevance to disease and mechanisms of evolution. Functional variation at genes that determine the ... -
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)The functional brain is critically dependent on a highly specific and perfectly timed gene-expression programme that underlies neuronal connectivity. Each step of this process, which includes cell migration, axon guidance, ... -
Exploring the role of granzymes in the induction of apoptosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Cytotoxic Lymphocytes (CTL) and Natural Killer (NK) cells provide the body with a powerful defence against viral infection, intracellular pathogens and tumor development. After identifying an infected or damaged cell, ... -
Controlled expression and functional characterisation of SasG - a surface protein of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Staphylococcus aureus colonises the moist squamous epithelium of the anterior nares. One of the adhesins likely to be responsible is the S. aureus surface protein G (SasG) which has sequence similarity with the proteins ... -
Genetic resistance to Campylobacter jejuni colonization in the chicken
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Campylobacter colonization levels within the chicken gastrointestinal tract vary substantially between individual chickens and this variation in colonization susceptibility can be heritable. In this work the genetic ... -
Protein coadaptation and the design of novel approaches to identify protein-protein interactions
(2011)Proteins rarely function in isolation but they form part of complex networks of interactions with other proteins within or among cells. The importance of a particular protein for cell viability is directly dependent upon ...
