Characterization of peptide mimics to antigens chaperoned by Hsp70 in MDA-MB-231 breast tumour cells
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Blanca Esther Arnaiz Villanueva, 'Characterization of peptide mimics to antigens chaperoned by Hsp70 in MDA-MB-231 breast tumour cells', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2005, pp 235Abstract:
Tumour-derived heat shock protein (Hsp) preparations have been shown to elicit
anti-tumour immune responses in both mice and man. Analysis of Hsp preparations
from tumour cells revealed that the immuno-protective property resides with the
peptides complexed with Hsps (Hsp-PCs). Clinical trials are on going using autologous
Hsp extracts as a source of antigens to boost immune responses against tumours. The
advantage of this vaccine is that no prior knowledge of the tumour antigens associated
with Hsps is required. The disadvantages are that it is patient-dependent and requires
invasive surgery.
Author: Arnaiz Villanueva, Blanca Esther
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Bond, UrsulaPublisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
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