dc.contributor.advisor | Atkins, Gregory | |
dc.contributor.author | Logue, Christopher H. | |
dc.date.accessioned | 2019-05-01T12:48:39Z | |
dc.date.available | 2019-05-01T12:48:39Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Christopher H. Logue, 'Sequence analysis of alphavirus pathogenesis', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2006, pp 245 | |
dc.identifier.other | THESIS 7888 | |
dc.description.abstract | This investigation involved the sequencing and characterisation of
Chikungunya virus (CHIKV), a positive-stranded RNA virus with a genome spanning
11.8 kb. The prototype strain of CHIKV, termed Ross was used. This is the first
complete genome of CHIKV to be sequenced and submitted to Genbank (Accession
No. AF490259). CHIKV was analysed in relation to six other geographically distinct
CHIKV strains and Semliki Forest virus which is well characterised in our laboratory.
This is the first report of CHIKV being characterised both in vitro and in vivo. The
rate of RNA production, rate of infection and cell tropism were investigated in vitro,
while the multiplication of virus in the brains of infected Balb/c mice, mortality rates,
and the neuropathology caused were studied in vivo. To fully ascertain the functions
of various CHIKV genes and their possible roles in causing disease, the construction
of a CHIKV full-length cDNA clone was subsequently carried out. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Microbiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12717704 | |
dc.subject | Microbiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Sequence analysis of alphavirus pathogenesis | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 245 | |
dc.description.note | TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/86445 | |