Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
Citation:
Mághnus N. O Séaghdha, 'Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2007, pp 249Download Item:
Abstract:
Staphylococcus aureus continues to be a major cause of infection in normal as well as
immunocompromised hosts, and the increasing prevalence of highly virulent community acquired
methicillin-resistant strains is a public health concern. Protein A (Spa) is a surface associated
protein of S. aureus best known for its ability to bind to the Fc region of IgG. This
interaction is of importance in resistance of S. aureus to phagocytosis. Spa also binds strongly
to the Fab region of the immunoglobulins bearing Vh3 heavy chains and more recently has
been shown to bind von Willebrand factor (vWF) and tumour necrosis factor receptor-1
(TNFR1). Each Spa domain is organized into a three helix bundle and binding sites for Fc and
VH3 Fab have been identified.
Author: O Séaghdha, Mághnus N.
Advisor:
Foster, TimPublisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisAvailability:
Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
Show full item recordLicences: