Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 81-100 of 622
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Submerged Eutectic-Assisted, Solvent-Free Mechanochemical Formation of a Propranolol Salt and Its Other Multicomponent Solids
(2021)Salt preparation via a solid-state reaction offers a solution to challenges posed by current pharmaceutical research, which include combining development of novel forms of active pharmaceutical ingredients with greener, ... -
Investigations of extracellular vesicles in triple-negative breast cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Breast cancer is the most commonly diagnosed cancer worldwide accounting for 11.7% of the newly diagnosed 19.3 million cases in 2020. In Ireland breast cancer accounted for 10.8% of cancer cases and 23.8% of female cancers. ... -
Characterisation and fundamental insight into the formation of new solid state, multicomponent systems of propranolol.
(2021)The physiochemical properties of acidic or basic active pharmaceutical ingredients (APIs) can be optimised by forming salts with different counterions. The aim of this work was to synthesise a novel salt of propranolol ... -
High-Pressure Dielectric Studies-a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures
(2021)In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix at ambient and elevated pressure conditions. Our studies confirmed that the solubility ... -
Formation of low melting point binary systems comprising ketoprofen and an amide local anaesthetic
(2021)Liquid forms of active pharmaceutical ingredients, ionic liquids (ILs) and deep eutectic mixtures (DEMs), offer several potential benefits in respect to advancing pharmaceutical formulations. The aim of this study was to ... -
Formation of stoichiometric and non-stoichiometric ionic liquid and cocrystal multicomponent phases of lidocaine with azelaic acid by changing counterion ratios
(2021)Tuning of physicochemical properties of ionic liquids and crystalline materials is a challenge that opens up unlimited possibilities for expanding applications and controlling biological activity of pharmaceutical ... -
Personal Electronic Records of Medications (PERMs) for medication reconciliation at care transitions: a rapid realist review.
(2021)Background Medication reconciliation (MedRec), a process to reduce medication error at care transitions, is labour- and resource-intensive and time-consuming. Use of Personal Electronic Records of Medications (PERMs) ... -
A Scientific Evaluation of Traditional Chinese Medicine (TCM): Houttuynia cordata Thunb Saururaceae - A Case Study
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Traditional Chinese Medicine (TCM) is one of the oldest medical systems in the world, still used for prevention or treatment of diseases in the modern China. It is a unique and holistic system, guided by ancient Chinese ... -
Extracellular vesicle separation from milk and infant milk formula using acid precipitation and ultracentrifugation
(2021)Separation of highly enriched extracellular vesicles (EVs) fractions from milk is desirable for quantification, cargo analysis, functional characterization, and investigation as delivery vehicles for nutrients and/or ... -
C6 glioma neuronal interactions and their moderation by the tryptophan-kynurenine metabolism pathway
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Brain glia possess the rate limiting enzyme indoleamine 2, 3-dioxygenase (IDO) which catalyses the conversion of tryptophan to kynurenine. Microglia also express kynurenine monooxygenase (KMO) and kynureninase (KYNU) which ... -
Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
(2021)To study and exploit extracellular vesicles (EVs) for clinical benefit as biomarkers, therapeutics, or drug delivery vehicles in diseases such as cancer, typically we need to separate them from the biofluid into which they ... -
Design and development of a hydrogel formulation with nanoparticles for the treatment of glioblastoma multiforme
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Glioblastoma multiforme (GBM) is the most aggressive form of brain tumours. GBM treatment is challenging because tumours are highly invasive and it is difficult to achieve effective therapeutic doses of drugs into the ... -
The relationship between antiepileptic drug load and challenging behaviors in older adults with intellectual disability and epilepsy
(2021)Antiepileptic drugs (AEDs) may affect mood and behavior in people with epilepsy and intellectual disability. A high AED load, derived from AED polytherapy and/or high doses of AEDs, has been suggested to be a risk factor ... -
Pharmacists involvement in COVID-19 vaccination across Europe: A situational analysis of current practice and policy
(2021)One year since the emergence of the COVID-19 pandemic, rapid response measures have been implemented internationally to mitigate the spread of the virus. Following rapid and successful pre-clinical and human trials, several ... -
Do assorted approaches aid in estimation of uronic acids? Case studies on Tinospora sinensis polysaccharides
(2014)Polysaccharides containing uronic acids are of immense biological significance. Colorimetric methods using different chromogens have been explored for uronic acid estimation in polysaccharides but these methods counter ... -
The antiviral potential of algal-derived macromolecules
(2021)A diverse range of molecules with anticancer, antiviral, and antibiotic activities has been identified and isolated from algal species. Such metabolites could address unmet clinical needs and be used to fight human diseases. ... -
Upgrading Methylation Method for Structural Studies of Polysaccharides: Case Analysis of a Bioactive Polysaccharide from Acacia tortilis.
(2020)Methylation has been the most widely used conventional tool in the structural characterization of polysaccharides. In the series of developments in methylation methods employing a diverse range of solvents and methylating ... -
Studies on Tinospora cordifolia monosugars and correlation analysis of uronic acids by spectrophotometry and GLC
(2014)Cold water-soluble (CWSP) and hot water soluble polysaccharides (HWSP) from Tinospora cordifolia stems were isolated and purified in 2.99% and 1.99% yield respectively. Complete hydrolysis followed by paper chromatography ... -
Extracellular polymeric substances in antarctic environments: A review of their ecological roles and impact on glacier biogeochemical cycles.
(2021)Antarctic continent comprises diverse ecosystems like snow, glacier ice, sea ice, melt pools, glacial soils, supraglacial and subglacial lakes that accommodate numerous microbial and algal communities. These biotic groups ...
