Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 61-80 of 622
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Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: implications for colonic secretory function.
(2022)The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important regulator of intestinal and metabolic function. Previous studies suggest that pentacyclic triterpenes (PCTs), a class of plant-derived bioactive ... -
A Precision Medicine Approach to Natriuretic Peptide-Guided Risk Prediction and Treatment: A Retrospective Analysis in the STOP-HF Cohort
Introduction: Individual studies show that NP-guided treatment is an effective intervention for the prevention of HF. We hypothesised that this approach may be optimised utilising a precision medicine approach. Methods: ... -
Development and characterisation of a humanised model of Parkinson's disease associated with delivery of adeno-associated virus expressing alpha-synuclein and pre-formed alpha-synuclein fibrils unilaterally into the rat substantia nigra
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Parkinson s disease (PD) is the most common motor neurodegenerative disease, characterised histologically by the presence of Lewy bodies, which are intracellular inclusions containing a variety of cellular proteins, the ... -
Characterisation of Depressive Symptoms in Huntington's Disease and of the Pharmacological Treatment for Depression: patterns, trends and Statistical Analysis of Enroll-HD Dataset
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: Huntington?s Disease (HD) is a rare autosomal dominant genetic disorder characterised by a triad of motor, psychiatric and cognitive symptoms. Among the psychiatric manifestations, depression is very common and ... -
Carissa spinarum L.: A Case Study in Ethnobotany and Bioprospecting Research
(Intech Open, 2022)This study explores ethnobiological and bioprospecting research through the lens of Carissa spinarum L., using it as a case study to examine wider trends in such research. Hunn’s Phasing in Ethnobiology is used as a ... -
Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
(2021)Medicinal plants have been used for a very long time to improve human health; they are gaining increasing popularity globally as drugs, complementary and alternative medicines, food supplements, cosmetics and, more surprisingly, ... -
Tumour microenvironment, extracellular vesicles and their effect on prostate cancer progression and docetaxel resistance
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Prostate cancer is the fourth most common cancer in Europe and the third leading cause of death in males. The standard of care as initial treatment for prostate cancer is, typically, androgen-deprivation therapy. Although ... -
Patterns of Medication Use Associated with Epilepsy and Comorbid Behavioural and Mental Disorders in Older People with Intellectual Disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: There is increasing concern worldwide regarding the levels of use and suboptimal prescribing of psychotropic medication in people with intellectual disability. Antipsychotics, in particular are often prescribed ... -
Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?
(2020)Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease ... -
Exploring the Irish National Folklore Ethnography Database (Dúchas) for Open Data Research on Traditional Medicine Use in Post-Famine Ireland: An Early Example of Citizen Science
(2020)A rich archive of oral and ethnological literature is housed in the National Folklore Collection, in University College Dublin, Ireland. The Schools' Manuscript Collection is one body of information that contains a wealth ... -
Medicine Maker: An Outreach Activity for Pharmaceutical Manufacturing and Health Literacy
(2022)Public engagement in medicine has become more important in promoting population health management and literacy. Medicine is a topic of great societal importance, and many public engagement activities have been developed ... -
An investigation into the use of ion-exchange resins as a formulation approach for modified-release oral liquid preparations
(Trinity College Dublin, Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)This thesis focuses on the use of ion-exchange resins (IERs) to modify the release profile of an active pharmaceutical ingredient (API) that would help address an unmet clinical need in the population if formulated as an ... -
Pre-Clinical In Vitro Models Used in Cancer Research: Results of a Worldwide Survey
(2021)To develop and subsequently get cancer researchers to use organotypic three-dimensional (3D) models that can recapitulate the complexity of human in vivo tumors in an in vitro setting, it is important to establish what in ... -
A method of separating extracellular vesicles from blood shows potential clinical translation, and reveals extracellular vesicle cargo gremlin-1 as a diagnostic biomarker
(2022)Extracellular vesicles (EVs) have potential as minimally invasive biomarkers. However, the methods most commonly used for EV retrieval rely on ultracentrifugation, are time-consuming, and unrealistic to translate to ... -
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
(2021)The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was ... -
Extracellular vesicle separation from milk and infant milk formula using acid precipitation and ultracentrifugation
(2021)Separation of highly enriched extracellular vesicles (EVs) fractions from milk is desirable for quantification, cargo analysis, functional characterization, and investigation as delivery vehicles for nutrients and/or ... -
Traditional Medicinal Knowledge documented in the Schools Manuscript Collection: An insight into the medical beliefs, practices and healing plants used in 1930s Ireland.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)The National Folklore Collection (NFC) in University College Dublin holds one of the largest collections of ethnographic material globally. In 2017, the Irish Folklore Commission Collection (1935-1970), housed within the ... -
Development and evaluation of novel, personalisable electronic counselling aids for patients starting Direct Oral Anticoagulants (DOACs)
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Comprehensive education for patients taking DOACs is essential to ensure treatment is safe and efficacious. The prescribing of DOACs has increased since becoming available on the European market in 2008, as evidence shows ... -
Interprofessional Education focused on Medication Safety: A Systematic Review.
(2022)Safe medication use necessitates interprofessional working, with calls to enhance interprofessional education (IPE) focusing on medication safety (MS) in healthcare professional (HCP) curricula. Little is known about the ... -
Chemical biology studies on human and mouse secondary bile acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Bile acids are important regulators of multiple homeostatic mechanisms integrating cell proliferation, metabolism and inflammation. The overall objective of this thesis was to use chemical biology tools to understand ...
