Physiology (Theses and Dissertations): Recent submissions
Now showing items 101-108 of 108
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The effect of neuronal insult on neurotrophin receptor expression and signalling
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)The neurotrophins were initially identified as a group of target-derived neuronal factors but have since been shown to mediate a wide range of biological functions including cell survival, maintenance, differentiation and ... -
A study of the potential of adult mesenchymal stem cells in bone and cartilage tissue engineering
(Trinity College (Dublin, Ireland). Department of Physiology, 2006)Adult mesenchymal stem cells (MSCs) have the potential to self-renew and differentiate into bone, cartilage, fat and muscle cells. This cell population offers significant potential for engineering of musculoskeletal tissue. ... -
An investigation of the effect of Tetrahydrocannabinol on the viability of cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Δ9-Tetrahydrocannabinol (THC), the principle psychoactive component of marijuana (Cannabis sativa), elicits diverse psychological effects in humans. THC exerts its central effects through the CB1 cannabinoid receptor, a ... -
Does IL-1F5 have anti-inflammatory actions in the brain?
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Similarity in structure and sequence homology has led to the identification of additional members of the IL-1 ligand and receptor superfamilies. Because of the importance of IL-1 in immune and inflammatory reactions, ... -
Modulation of inflammatory changes in the rat hippocampus by atorvastatin
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Inflammatory changes, typified by an increase in pro-inflammatory cytokine production and upregulation of corresponding signalling pathways, have been consistently shown in the brain of aged animals and animals treated ... -
Methylenenedioxymethamphetamine (MDMA Ecstasy) suppresses the innate immune system : a critical role for the anti-inflammatory cytokine interleukin-10
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)3,4-methylenedioxymethamphetamine (MDMA; “Ecstasy”) is a ring-substituted phenylisopropylamine and globally abused drug that has been implicated to have immunosuppressive effects in animals and humans. Here MDMA was shown ... -
Carbohydrate versus caffeinated-carbohydrate beverages: effects on exercise performance and hydration status at rest and during exercise
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Carbohydrate versus caffeinated-carbohydrate beverages: effects on exercise performance and hydration status at rest and during exercise. The consumption of sports drinks to enhance athletic performance had been the subject ... -
Effect of the beta₂-adrenoceptor agonist clenbuterol on inflammatory signalling in the CNS and behaviour
(Trinity College (Dublin, Ireland). Department of Physiology, 2012)This thesis explored the anti-inflammatory and neuroprotective properties elicited by stimulation of the noradrenergic receptor, the P2-adrenoceptor, in the rat brain. Neuroinflammation is a feature of many chronic ...
