Biochemistry (Scholarly Publications): Recent submissions
Now showing items 441-460 of 734
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Membrane Protein Crystallization in Lipidic Mesophases. Hosting lipid affects on the crystallization and structure of a transmembrane peptide.
(2011)Gramicidin is an apolar pentadecapeptide antibiotic consisting of alternating D-and L-amino acids. It functions, in part, by creating pores in membranes of susceptible cells rendering them leaky to monovalent cations. ... -
Crystallizing Membrane Proteins in Lipidic Mesophases. A Host Lipid Screen
(2011)The default lipid for the bulk of the crystallogenesis studies performed to date using the cubic mesophase method is monoolein. There is no good reason however, why this 18-carbon, cis - monounsaturated monoacylglycerol ... -
Crystallizing membrane proteins for structure determination using lipidic mesophases.
(2010)A detailed protocol for crystallizing membrane proteins by using lipidic mesophases is described. This method has variously been referred to as the lipidic cubic phase or in meso method. The method has been shown to be ... -
Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei
(2013)Flagellar attachment is a visibly striking morphological feature of African trypanosomes but little is known about the requirements for attachment at a molecular level. This study characterizes a previously undescribed ... -
Nutrient ingestion increased mTOR signaling, but not hVps34 activity in human skeletal muscle after sprint exercise.
(2013)Nutrient provision after sprint exercise enhances mammalian target of rapa- mycin (mTOR) signaling. One suggested that nutrient sensor is the class III phosphatidylinositol 3-kinase, vacuolar protein sorting 34 (Vps34), ... -
Circadian Clock Proteins and Immunity
(2014)Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow an organism to anticipate daily changes in ... -
The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10.
(2014)MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukaemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role ... -
Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection
(2013)Pegylated-IFN and ribavirin remains the current treatment for chronic HCV infection in patients co-infected with HIV-1, but this regimen has low efficacy rates, particularly for HCV genotype 1/4 infection, has severe side ... -
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
(2012)TLR4 signaling is inhibited by poxviral protein A46, but the mechanism is unknown. Results: We identify the protein interaction surfaces within the TLR4 complex that A46 antagonises, and characterize the interaction between ... -
HUMAN INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE-2 (IRAK-2) IS ESSENTIAL FOR TOLL-LIKE RECEPTOR-MEDIATED TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF TNFα
(2011)Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NF?B and MAPKs such ... -
Innate sensing of bacterial cyclic dinucleotides: More than just STING
(2012)Bacterial cyclic dinucleotides are recognised by the innate immune system, leading to induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway ... -
Recognition of herpesviruses by the innate immune system
(2011)Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on ... -
Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.
(2013)If DNA accumulates in the cytosol it activates innate immunity via recently described DNA sensors. In this issue of Immunity Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has ... -
Recent insights into the role of Toll-like receptors in viral infection.
(2010)Toll-like receptors have a central role in innate immunity as they detect conserved pathogen associated molecular patterns (PAMPs) on a range of microbes including viruses, leading to innate immune activation and ... -
Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule
(2010)TLRs are critical pattern recognition receptors, which recognize bacterial and viral pathogen associated molecular patterns leading to innate and adaptive immune responses. TLRs signal via homotypic interactions between ... -
The role of non-degradative ubiquitination in interleukin-1 and Toll-like receptor signalling.
(2009)The induction of an appropriate immune response upon infection of an invading pathogen is controlled by host pattern recognition receptors (PRRs)* that specifically recognise essential structural components of infectious ... -
Innate DNA Sensing Moves to the Nucleus
(2011)It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus ... -
Cytosolic DNA sensors regulating type I interferon induction
(2011)Type I interferon induction is a critical anti-pathogen response mediated by innate immune stimulation. While it has been appreciated for some time that the presence of pathogen DNA within a cell leads to a type I ...
