Browsing Microbiology (Theses and Dissertations) by Subject "Ph.D. Trinity College Dublin"
Now showing items 21-40 of 60
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Epidemiology of Streptococcus agalactiae (Group B Streptococci) in Dublin Maternity Hospitals
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Streptococcus agalactiae (Group B Streptococci) are Gram-positive encapsulated cocci distinguished from other streptococci by their narrower zones of P-haemolysis. Group B Streptococci (GBS) was first described as an ... -
Fibronectin-binding protein B variation in straphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)The surface-expressed fibronectin-binding proteins FnBPA and FnBPB of Staphylococcus aureus mediate attachment to immobilised fibronectin, fibrinogen and elastin. These proteins are encoded by two closely linked but ... -
Gene regulation and the Fis nucleoid-associated protein in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)The Fis protein was found to influence the superhelical density of DNA and its ability to do this differed between Salmonella enterica serovar Typhimurium (S. typhimurium) and Escherichia coli (E. coli). Induction of the ... -
Gene regulation and the leucine-responsive regulatory protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The leucine-responsive regulatory protein of Escherichia coli (E. coli) is a well characterised global regulator of transcription. Comparatively little is known about the Lrp regulon of Salmonella enterica serovar ... -
Genetic diversity of Helicobactor pylori isolates through Microevolution in vivo
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Chronic infection with H. pylori causes peptic ulcer disease and its presence is strongly linked with gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. One of the most interesting characteristics ... -
Helicobacter pylori infection : in vitro diagnostic methods, antimicrobial susceptibility testing, epidemiology of recrudescence and clarithromycin resistance
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)H. pylori is a Gram-negative, non-spore forming, curved bacterium that colonises the gastric epithelium of the human stomach. H. pylori is firmly established as an aetiological agent in peptic ulcer disease and successful ... -
High-throughput investigation of virulence gene regulation by sRNAs in Salmonella Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)This study focused on novel gene regulatory systems in Salmonella enterics serovar Typhimurium, a model gram-negative, bacterial pathogen. The sRNA-mediated control of virulence genes was a particular emphasis. The research ... -
Identification and characterisation of an FK506-binding protein from Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Malaria remains one of the most significant diseases worldwide. The most common and severe form of the disease is caused by Plasmodium falciparum. The need for new anti-malarial compounds has intensified in recent years ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-borne apicomplexan Plasmodium falcipanim. The lack of an effective vaccine coupled with ... -
Identification of factors involved in 3' end processing and transcription termination of histone mRNAs
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)The production of core histone mRNAs is tightly regulated during the cell cycle in all eukaryotic cells. Histone mRNAs accumulate during the S-phase and are subsequently degraded upon entry into G2-phase of the cell cycle. ... -
Immune responses to cereal prolamin proteins in coeliac disease
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Coeliac disease is an inflammatory disease of the small intestine, precipitated in susceptible individuals by gliadin, the alcohol soluble (prolamin) fraction of wheat gluten. There is a strong genetic influence on ... -
Interaction of heat shock proteins with splicing machinery components during and after thermal stress in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)This thesis is a study of the amehorative effects of Heat Shock Proteins (Hsps) on the cellular process of mRNA splicing during and after thermal stress in Saccharomyces cerevisiae. Splicing is a vital process that is known ... -
Investigating the transcriptional regulation of small RNA expression in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important foodborne pathogen that causes self-limiting gastroenteritis, or more serious systemic infections in susceptible hosts. S. Typhimurium can infect a ... -
Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Eukaryotic genomes are organised as the DNA-protein complex, chromatin within the cell nucleus. The fundamental subunit of chromatin is the nucleosome, which comprises 146 base pairs of DNA wrapped around an octamer of ... -
Investigation of herbicide-based compounds as novel anti-malarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Plasmodium falciparum causes the most severe form of malaria in humans. Currently, no effective vaccine exists and the emergence of widespread drug resistance in the parasite has further increased the necessity for novel ... -
Investigation of microtubule inhibitors as potential antimalarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-bome apicomplexan parasite Plasmodium falciparum. The lack of an effective vaccine coupled ... -
Investigation of Plasmodium falciparum aminopeptidases and characterisation of the M17 leucine aminopeptidase
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Plasmodium falciparum spends part of its life cycle residing in human erythrocytes, during which time it digests much of the host cell haemoglobin to provide a source of amino acids for synthesis of its own proteins. The ... -
Investigation of the transcriptional landscape and RNA biology of Salmonella Typhimurium plasmids
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Investigations into the pathogenesis of Dengue virus infections of humans : the endothelium as a target
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)The pathogenesis of the disease Dengue Haemorrhagic Fever/Dengue Shock Syndrome has not been elucidated. This study investigated the effects of Dengue virus, serotype 2 infection on both the human cell line ECV304/T-24 ... -
Microevolution in Helicobacter pylori
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Helicobacter pylori chronically colonises the human gastric mucosa. It is a major cause of chronic active gastritis and peptic ulcer disease and is associated with the development of gastric neoplasia. The population ...