Browsing Microbiology (Theses and Dissertations) by Title
Now showing items 29-48 of 87
-
FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ... -
Functional characterisation of small RNAs in Acinetobacter baumannii using Hi-GRIL-seq
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Acinetobacter baumannii is a priority pathogen that is a leading source of nosocomial multidrug resistant (MDR) infections worldwide. A key to the success of A. baumannii is the ability to quickly adapt to changing ... -
Gene regulation and the Fis nucleoid-associated protein in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)The Fis protein was found to influence the superhelical density of DNA and its ability to do this differed between Salmonella enterica serovar Typhimurium (S. typhimurium) and Escherichia coli (E. coli). Induction of the ... -
Gene regulation and the leucine-responsive regulatory protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The leucine-responsive regulatory protein of Escherichia coli (E. coli) is a well characterised global regulator of transcription. Comparatively little is known about the Lrp regulon of Salmonella enterica serovar ... -
Genetic and Molecular Studies of Virulence Factors of Staphylococcus aureus
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023) -
Genetic diversity of Helicobactor pylori isolates through Microevolution in vivo
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Chronic infection with H. pylori causes peptic ulcer disease and its presence is strongly linked with gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. One of the most interesting characteristics ... -
Helicobacter pylori infection : in vitro diagnostic methods, antimicrobial susceptibility testing, epidemiology of recrudescence and clarithromycin resistance
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)H. pylori is a Gram-negative, non-spore forming, curved bacterium that colonises the gastric epithelium of the human stomach. H. pylori is firmly established as an aetiological agent in peptic ulcer disease and successful ... -
High-throughput investigation of virulence gene regulation by sRNAs in Salmonella Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)This study focused on novel gene regulatory systems in Salmonella enterics serovar Typhimurium, a model gram-negative, bacterial pathogen. The sRNA-mediated control of virulence genes was a particular emphasis. The research ... -
Identification and characterisation of an FK506-binding protein from Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Malaria remains one of the most significant diseases worldwide. The most common and severe form of the disease is caused by Plasmodium falciparum. The need for new anti-malarial compounds has intensified in recent years ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-borne apicomplexan Plasmodium falcipanim. The lack of an effective vaccine coupled with ... -
Identification of factors involved in 3' end processing and transcription termination of histone mRNAs
(Trinity College (Dublin, Ireland). Department of Microbiology, 2011)The production of core histone mRNAs is tightly regulated during the cell cycle in all eukaryotic cells. Histone mRNAs accumulate during the S-phase and are subsequently degraded upon entry into G2-phase of the cell cycle. ... -
Immune responses to cereal prolamin proteins in coeliac disease
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Coeliac disease is an inflammatory disease of the small intestine, precipitated in susceptible individuals by gliadin, the alcohol soluble (prolamin) fraction of wheat gluten. There is a strong genetic influence on ... -
Impact of Metabolites on the Intestinal Mucosa and Development of Inflammation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)The intestinal epithelial mucosal barrier plays a pivotal role in the maintenance of intestinal homeostasis, acting as an important barrier between microbes and the host s innate immune system. The metabolite-rich environment ... -
Interaction of heat shock proteins with splicing machinery components during and after thermal stress in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)This thesis is a study of the amehorative effects of Heat Shock Proteins (Hsps) on the cellular process of mRNA splicing during and after thermal stress in Saccharomyces cerevisiae. Splicing is a vital process that is known ... -
Investigating chromatin remodelling by the Swi-Snf and Tup1-Cyc8 complexes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)Swi-Snf is an ATP-dependent chromatin remodelling complex which generally acts as a co-activator of gene transcription via its removal of promoter nucleosomes. Conversely, Tup1-Cyc8 (Ssn6) is a co-repressor complex which ... -
Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)The skin of atopic dermatitis (AD) patients is frequently colonised by Staphylococcus aureus. Colonisation by S. aureus correlates with disease severity and exacerbated disease symptoms. The factors involved in S. aureus ... -
Investigating influenza virus A pleomorphy
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)Clinical isolates of influenza A virus particles display a pleomorphic phenotype, where particles can range in size from 100 nm to 10 ?m in length while maintaining uniform diameters. Conversely, most laboratory-adapted ... -
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Transcriptional repression is an important part of gene regulation. In the budding yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to gene promoters to repress transcription in response to ... -
Investigating the interplay between the Tup1-Cyc8 and Swi-Snf chromatin remodelling complexes in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Swi-Snf is an ATP dependent chromatin remodelling complex which acts as a co-activator of gene transcription by its ability to open up densely packed chromatin by removal of nucleosomes. Conversely, Tup1-Cyc8 ... -
Investigating the potential to source novel postbiotics with anti-microbial or immune-modulatory activity from distillery waste
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The purpose of this project is to find a novel source for antimicrobial and immunomodulatory compounds. Here we investigate the antimicrobial and immunomodulatory potential of postbiotics sourced from whisky distillation. ...