Browsing Microbiology (Theses and Dissertations) by Title
Now showing items 49-68 of 87
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Investigating the transcriptional regulation of small RNA expression in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important foodborne pathogen that causes self-limiting gastroenteritis, or more serious systemic infections in susceptible hosts. S. Typhimurium can infect a ... -
Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Eukaryotic genomes are organised as the DNA-protein complex, chromatin within the cell nucleus. The fundamental subunit of chromatin is the nucleosome, which comprises 146 base pairs of DNA wrapped around an octamer of ... -
Investigating Tup1-Cyc8 complex function in Saccharomyces cerevisiae following the confirmation and characterization of a TUP1 conditional mutant
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023)The Tup1-Cyc8 complex is a well-defined corepressor complex found in S. cerevisiae. It is known to regulate close to 3% of all yeast genes and has orthologs reported in mammals. Its exact functioning is not well-understood. ... -
Investigation of herbicide-based compounds as novel anti-malarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Plasmodium falciparum causes the most severe form of malaria in humans. Currently, no effective vaccine exists and the emergence of widespread drug resistance in the parasite has further increased the necessity for novel ... -
Investigation of microtubule inhibitors as potential antimalarial agents
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-bome apicomplexan parasite Plasmodium falciparum. The lack of an effective vaccine coupled ... -
Investigation of Plasmodium falciparum aminopeptidases and characterisation of the M17 leucine aminopeptidase
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Plasmodium falciparum spends part of its life cycle residing in human erythrocytes, during which time it digests much of the host cell haemoglobin to provide a source of amino acids for synthesis of its own proteins. The ... -
Investigation of the cellular location of Multicopper Oxidase and its contribution to copper tolerance and immune resistance in Staphylococcus aureus
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2022)In high amounts copper exerts toxic effects on bacteria, and therefore its cellular concentrations must be tightly controlled. Staphylococcus aureus is a WHO priority pathogen responsible of an enormous burden on healthcare ... -
Investigation of the transcriptional landscape and RNA biology of Salmonella Typhimurium plasmids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014) -
Investigations into the pathogenesis of Dengue virus infections of humans : the endothelium as a target
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)The pathogenesis of the disease Dengue Haemorrhagic Fever/Dengue Shock Syndrome has not been elucidated. This study investigated the effects of Dengue virus, serotype 2 infection on both the human cell line ECV304/T-24 ... -
Microevolution in Helicobacter pylori
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Helicobacter pylori chronically colonises the human gastric mucosa. It is a major cause of chronic active gastritis and peptic ulcer disease and is associated with the development of gastric neoplasia. The population ... -
Molecular analysis of surface proteins of staphylococci
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)S. lugdunensis is an important human pathogen that causes 44% of coagulase negative staphylococcal native valve endocarditis as well as infections such as osteomyelitis and soft tissue abscesses. S. lugdunensis expresses ... -
Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ... -
Molecular characterisation of agn43 and its encoded protein, antigen 43, the major phase-variable outer membrane protein of Escherichia coli
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)A number of year ago workers in this laboratory identified antigen 43 (Ag43) during a systematic immunochemical analysis of the envelopes of Escherichia coli ML308-225 O13:O68:H . This Escherichia-specific outer membrane ... -
Molecular characterisation of Region A of FnBPA from Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The surface-expressed fibronectin-binding proteins, FnBPA and FnBPB, of Staphylococcus aureus promote attachment to immobilised fibrinogen and elastin via the N-Terminal A region. The N2N3 subdomains of region A were found ... -
Molecular characterisation of the Salmonella-specific protein PagN
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Salmonella infect a broad spectrum of animals resulting in host responses ranging from severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as fever or self-limiting gastroenteritis. ... -
Molecular genetic typing characteristics of human and animal isolates of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Staphylococcus aureus is a commensal and an opportunistic pathogen of both man and animals. It is capable of causing a broad spectrum of diseases, ranging in severity from superficial skin complaints such as boils and ... -
Molecular genetic typing of Staphylococcus aureus from cows, goats, sheep, rabbits and chickens
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is an important pathogen of man causing a range of infections from boils, carbuncles and abscesses to more serious and life-threatening infections like endocarditis and osteomyelitis. S. aureus is ... -
Platelet activation by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ... -
Preventing protein-dependent biofilm formation in Staphylococcus aureus by targeting the serine aspartate repeat protein C and fibronectin binding proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Staphylococcus aureus is a leading cause of biofilm infections on indwelling medical devices. S. aureus biofilm infections are intrinsically difficult to treat. They are recalcitrant to conventional antibiotics and resistant ... -
Recombinant vaccines against infectious pancreatic necrosis virus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)The rapid expansion of the aquaculture industry in recent years has led to an increase in disease outbreaks. Over the last few years bacterial disease problems have been brought under control, largely due to the use of a ...