Microbiology (Theses and Dissertations): Recent submissions
Now showing items 21-40 of 87
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Molecular genetic typing characteristics of human and animal isolates of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Staphylococcus aureus is a commensal and an opportunistic pathogen of both man and animals. It is capable of causing a broad spectrum of diseases, ranging in severity from superficial skin complaints such as boils and ... -
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Transcriptional repression is an important part of gene regulation. In the budding yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to gene promoters to repress transcription in response to ... -
Discovery and engineering of antimicrobial peptides to combat food spoilage
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)This work sought to use a bioinformatics based approach to discover plant derived antimicrobial peptides which were structurally similar to human β-defensin 3 (HBD3) and which possessed effective antimicrobial activity ... -
FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ... -
Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)The skin of atopic dermatitis (AD) patients is frequently colonised by Staphylococcus aureus. Colonisation by S. aureus correlates with disease severity and exacerbated disease symptoms. The factors involved in S. aureus ... -
Analysis of the role of human papillomaviruses and the p53/Rb tumour suppressor genes in the development of cutaneous squamous cell carcinoma
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)Nonmelanoma skin cancers (NMSC) are the most frequent cancers in Caucasian populations. Renal transplant recipients (RTR) are at an increased risk of neoplasia, particularly skin cancer. Studies on anogenital cancer have ... -
Identification and characterisation of an FK506-binding protein from Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Malaria remains one of the most significant diseases worldwide. The most common and severe form of the disease is caused by Plasmodium falciparum. The need for new anti-malarial compounds has intensified in recent years ... -
Recombinant vaccines against infectious pancreatic necrosis virus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)The rapid expansion of the aquaculture industry in recent years has led to an increase in disease outbreaks. Over the last few years bacterial disease problems have been brought under control, largely due to the use of a ... -
Variations in silver stained nucleolar organiser regions(AgNORs) in normal, irradiated and neoplastic tissues
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Nucleolar organiser regions (NORs) are loops of ribosomal DNA which contain the genes that transcribe to ribosomal RNA. They are situated on the short arm of the acrocentric human chromosomes 13, 14, 15, 21 and 22. Several ... -
Helicobacter pylori infection : in vitro diagnostic methods, antimicrobial susceptibility testing, epidemiology of recrudescence and clarithromycin resistance
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)H. pylori is a Gram-negative, non-spore forming, curved bacterium that colonises the gastric epithelium of the human stomach. H. pylori is firmly established as an aetiological agent in peptic ulcer disease and successful ... -
Interaction of heat shock proteins with splicing machinery components during and after thermal stress in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)This thesis is a study of the amehorative effects of Heat Shock Proteins (Hsps) on the cellular process of mRNA splicing during and after thermal stress in Saccharomyces cerevisiae. Splicing is a vital process that is known ... -
Microevolution in Helicobacter pylori
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Helicobacter pylori chronically colonises the human gastric mucosa. It is a major cause of chronic active gastritis and peptic ulcer disease and is associated with the development of gastric neoplasia. The population ... -
Analysis of the genomic organisation and gene expression of brewery strains of yeast
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)The genomes of lager yeast arose from the fusion of two yeast strains most closely resembling Saccharomyces cerevisiae and Saccharomyces bayanus. The resultant strains have subsequently undergone genome duplications ... -
Molecular genetic typing of Staphylococcus aureus from cows, goats, sheep, rabbits and chickens
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is an important pathogen of man causing a range of infections from boils, carbuncles and abscesses to more serious and life-threatening infections like endocarditis and osteomyelitis. S. aureus is ... -
The Dps protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)As a nucleoid-associated protein, Dps has long been thought to influence gene expression at a global level. In this study the role of Dps in genetic regulation in Salmonella enterica serovar Typhimurium was investigated. ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-beta on the progression of experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Multiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS, characterized by the presence of sclerotic lesions throughout the brain. MS is thought to be a CD4+ T helper 1 disease caused by the infiltration ... -
Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This ... -
Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ... -
The cell biology of microtubule inhibition in Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Malaria is among the most prevalent human infections worldwide and both the lack of a viable vaccine and the spread of resistance to commonly used drugs have limited the options for control of the parasite, especially ... -
Molecular analysis of surface proteins of staphylococci
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)S. lugdunensis is an important human pathogen that causes 44% of coagulase negative staphylococcal native valve endocarditis as well as infections such as osteomyelitis and soft tissue abscesses. S. lugdunensis expresses ...