Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 201-220 of 355
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Molecular aspects of human lipid metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The postprandial lipaemic response refers to the changes in lipid and lipoprotein concentrations after consumption of a meal containing more than 15g of long-chain fatty acids. The magnitude and duration of the response ... -
Tumourigenesis and resistance to Interferon alpha-treatment in Cutaneous T-cell Lymphoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Mycosis fungoides (MF) is a Cutaneous T-Cell lymphoma (CTCL) of unknown aetiology, and the mechanisms of tumourigenesis of this lymphoma are unclear. The diagnosis of MF is extremely challenging due to the fact that, in ... -
The role of folate in the development of colorectal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Colorectal cancer is a leading cause of morbidity and mortality in Europe and the USA each year. Most large bowel cancers arise within pre-existing adenomatous polyps or adenomas. Several case-control and prospective studies ... -
The pathophysiology of insulin resistance and modulation by aerobic exercise in obese and Type 2 diabetes subjects
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Insulin resistance is a major contributing factor to the development of Type 2 diabetes and cardiovascular disease. It has been difficult to characterise the aetiological progression because of the complex metabolic milieu ... -
Development of an antisense strategy to down-regulate gene expression in chronic myelogenous leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Since the discovery of mRNA down-regulation by sequences of complementary nucleic acids in 1977, there has been a drive to apply the antisense phenomenon to therapeutic settings. In theory the potential of antisense ... -
Surface layer proteins of Clostridium difficile as novel vaccine candidates
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Clostridium difficile is a major cause of antibiotic associated diarrhoea and pseudomembranous colitis in hospitalised patients. The major precipitating factor for C. difficile-associated disease (CDAD) is disruption of ... -
An extensive evaluation of the validity of reported energy intakes in the North/South Ireland food consumption survey
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)The North/South Ireland Food Consumption Survey (NSIFCS) was conducted between 1997 and 1999, on a representative sample of 1379 adults from the Republic of Ireland and Northern Ireland, aged 18 to 64 years. Food intakes ... -
The role of the bile acid deoxycholate in gastrointestinal epithelial cell signalling
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Environmental and dietary factors are implicated in the aetiology of human cancer. Bile acids, the amphiphilic derivatives of cholesterol, are strongly implicated in colonic and oesophageal carcinogenesis. While bile acids ... -
Novel molecular targets in advanced prostate cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Prostate Cancer (PCa) is the most commonly diagnosed cancer in men and a leading cause of morbidity and mortality among men in the United States and Western Europe. The aim of initial treatment in advanced PCa is to reduce ... -
An exploration of the referral patterns of a community palliative care team to specialist palliative care outpatient physiotherapy for community based individuals with advanced cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Introduction: Physiotherapy is a core discipline within specialist palliative care (SPC) services and has been shown to contribute to the management of common symptoms associated with advanced cancer such as fatigue, ... -
Characterisation of the redox protein Thioredoxin from the gastric pathogen Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Gastric colonisation by the Gram-negative bacterium Helicobacter pylori is the primary cause of peptic ulceration, type B chronic gastritis, gastric adenocarcinoma, and is linked to the progression of gastric MALT lymphoma. ... -
Chracterisation of the Epithelial barrier in early life and in atopic dermatitis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Atopic dermatitis (AD) is the most common inflammatory disease of childhood. It is characterised clinically by chronic skin inflammation and pruritus. Atopic dermatitis is associated with several co-morbidities, including ... -
Antimicrobial susceptibility, resistance determinants and molecular epidemiology of Neisseria gonorrhoeae in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health ... -
Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ... -
The nerve of facial expression, impact of its anatomical variations on iatrogenic surgical injury and a novel MRI diffusion weighted imaging technique to image its intra-parotid course
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)This doctorate in clinical medicine set out to assess how variations in facial nerve anatomy to the intra-parotid venous system could impact on surgical access to the parotid gland or the mandible, and explored methods to ... -
Examining links between Factor Xa, endothelial dysfunction, adverse pregnancy outcomes and cardiovascular disease in Lupus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Systemic lupus erythematosus (SLE) is a multisystemic autoimmune rheumatic disease (ARD) associated with significant morbidity and mortality, which presents mainly in women of childbearing age. Women with SLE have a 5-10-fold ... -
Transcriptional response to prolonged acid exposure and genetic divergence in Helicobacter pylor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Helicobacter pylori infection is strongly associated with gastritis, peptic ulcer and gastric adenocarcinoma. Molecular mechanisms involved in H. pylori adaptation and clinical consequences of infection are unclear. This ... -
The nutritional status of hospital patients and healthy elderly living in the community
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Protein-energy undernutrition is known to occur in patients on admission to hospital. In a prospective study of 594 sequential hospital admissions, we assessed the prevalence of undernutrition among patients on admission ... -
Assessment of platelet activation and function in the early and late phases following acute TIA and ischaemic stroke
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Aims: The purpose of this thesis was to comprehensively assess the impact of commencing commonly prescribed antiplatelet regimens on platelet activation, platelet function and platelet turnover after TIA or ischaemic stroke, ... -
Investigation of interactions of nanoparticles with components of the human vascular microenvironment : platelets, plasma and endothelial cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Nanotechnology is defined as ‘the understanding and control of matter at dimensions less than 100 nanometers’, and exploits the novel physical, chemical and biological properties of materials. Nanomedicine, application of ...
